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TranscriptomicsKnockdown of Atoh8 in Neurog3-expressing mouse ductal cells mPAC results in altered expression of multiple cell cycle related genes
Atoh8 is a transcription factor of the basic-helix-loop-helix (bHLH) family that is expressed in multiple tissues during embryonic development but whose specific functions remain unknown. The gene encoding Atoh8 is induced by various lineage- determining bHLH transcription factors in cell culture, ...
ORGANISM(S): Mus musculus 
2014-10-10 | E-GEOD-43536 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse pancreatic duct cell lines infected with Ngn3-expressing adenovirus
We have developed an in vitro model of Ngn3-dependent differentiation by infecting pancreatic duct cell lines with an Ngn3-expressing adenovirus. We used glass microarrays containing 18,000 mouse cDNAs and compared gene expression patterns in mPAC L20 cells infected with either AdCMV-gal (control) o...
ORGANISM(S): Mus musculus 
2006-07-25 | E-CBIL-15 | biostudies-arrayexpress
TranscriptomicsINDUCTION OF PANCREATIC ISLET CELL DIFFERENTIATION BY THE NEUROGENIN-NEUROD CASCADE
Neurog3 and NeuroD1 share the ability to induce endocrine differentiation when expressed ectopically in vivo (Apelqvist et al., 1999; Schwitzgebel et al., 2000; Grapin-Botton et al., 2001) and in vitro (Heremans et al., 2002; Gasa et al., 2004), suggesting that they target a common set of genes. To...
ORGANISM(S): Mus musculus 
2007-08-29 | E-GEOD-7884 | biostudies-arrayexpress
TranscriptomicsThe role of Raf-1 kinase inhibitor protein in the regulation of pancreatic beta cell proliferation in mice
AIMS/HYPOTHESIS: Manoeuvres aimed at increasing beta cell mass have been proposed as regenerative medicine strategies for diabetes treatment. Raf-1 kinase inhibitor protein 1 (RKIP1) is a common regulatory node of the mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB) pathways and...
ORGANISM(S): Mus musculus 
2012-11-19 | E-GEOD-31150 | biostudies-arrayexpress
TranscriptomicsEffects of sodium tungstate administration in Irs2 -/- mice
Relative beta cell deficit and increased beta cell apoptosis are hallmarks of type 2 diabetes (T2D). The Insulin/Insulin Growth Factor (Igf) signaling pathway is an established regulator of beta cell survival and is found downregulated in human T2D islets. The Insulin Receptor Substrate 2 (Irs2) pla...
ORGANISM(S): Mus musculus 
2014-01-19 | E-GEOD-43620 | biostudies-arrayexpress
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