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Proteomicsthermal proteome profiling study on Haemonchus contortus
Parasitic diseases of humans and other animals represent a major socioeconomic burden worldwide. In humans, parasitic worms (helminths) that cause neglected tropical diseases (NTDs) affect ~ billion people, equating to a burden of >12 million disability-adjusted life years (DALYs) (Hotez et al., 201...
ORGANISM(S): Caenorhabditis elegans 
2022-09-25 | PXD034868 | Pride
Haemonchus contortus  tpp  lc-ms/ms 
ProteomicsSarcoptes scabiei somatic proteomes
Presently, there is a dearth of proteomic data for parasitic mites and their relationship with the host animals. Here, using a high throughput LC-MS/MS-based approach, we undertook the first comprehensive, large-scale proteomic investigation of egg and adult female stages of the scabies mite, Sarcop...
ORGANISM(S): Sarcoptes scabiei 
2022-11-11 | PXD032148 | Pride
Proteomes  sarcoptes scabiei  parasitic mite  egg and adult stages  scabies  human 
ProteomicsABX464 – structure-activity relationship in a model parasitic nematode and target deconvolution
Within the context of our anthelmintic discovery program, we recently identified and evaluated a quinoline derivative, called ABX464 or obefazimod, as a nematocidal candidate; synthesised a series of analogues which were assessed for activity against the free-living model nematode Caenorhabditis ele...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2024-02-07 | PXD046553 | Pride
Nematode Lc-ms/ms 
ProteomicsAssessment of the nematocidal potency of ABX464 analogues and target deconvolution in Caenorhabditis elegans by thermal proteome profiling
Global challenges with anthelmintic failure and resistance development lends impetus to the development of new nematocides (anthelmintics) with novel mechanism(s) of action. The free-living nematode Caenorhabditis elegans is as an important model organism used for drug discovery and a powerful tool...
ORGANISM(S): Caenorhabditis elegans 
2024-01-29 | PXD042930 | Pride
Thermal proteome profiling  lc-ms/ms  caenorhabditis elegans 
ProteomicsComparative exploration of the anthelmintic candidate KM08948 in Haemonchus contortus and Caenorhabditis elegans
Infections and diseases caused by parasitic nematodes have a major adverse impact on the health and productivity of animals and humans worldwide. The control of these parasites often relies heavily on the treatment with commercially available chemical compounds (anthelmintics). However, the excessiv...
ORGANISM(S): Haemonchus contortus (Barber pole worm) Caenorhabditis elegans 
2024-04-22 | PXD048945 | Pride
Haemonchus contortus Caenorhabditis elegans Lc-ms/ms 
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