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MetabolomicsMedicarpin suppresses gastric cancer growth through modulation of mevalonate pathway-associated cholesterol biosynthesis
Background: Gastric cancer (GC) is an aggressive malignancy characterized by metabolic reprogramming, including dysregulated cholesterol biosynthesis. Medicarpin (Med), a natural isoflavan isolated from Radix Hedysari, has shown pharmacological potential; however, its anti-GC activity and metabolic ...
2026-10-02 | MTBLS15900 | MetaboLights
ProteomicsA Proteomic Survey of Enzymes in the Plasma and Gastric Fluid of Burmese Python
Background: Exceptional and extreme feeding behaviour makes the Burmese python (Python bivittatus) an interesting model to study physiological remodelling and metabolic adaptation in response to refeeding after prolonged starvation. In this study, we used transcriptome sequencing of five visceral o...
ORGANISM(S): Python bivittatus 
2018-10-24 | PXD006665 | Pride
Gastric fluid Burmese python Plasma Lc-ms/ms 
TranscriptomicsInsight into Vibrio parahaemolyticus CHN25 response to artificial gastric fluid stress by transcriptomic analysis
Vibrio parahaemolyticus is the causative agent of food-borne gastroenteritis disease. Once consumed, human acid gastric fluid is perhaps one of the most important environmental stresses imposed on the bacterium. Herein, for the first time, we investigated Vibrio parahaemolyticus CHN25 response to ar...
ORGANISM(S): Vibrio parahaemolyticus 
2015-06-30 | E-GEOD-63167 | biostudies-arrayexpress
TranscriptomicsGastric Cancer Cell Lines
Regions of recurrent genomic amplification and deletion are frequently observed in primary gastric cancers (GC). However, identifying specific oncogenes and tumor suppressor genes within these regions can be challenging, as they often cover tens to hundreds of genes. Here, we combined high-resolutio...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-10611 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human gastric cancer cells after treatment with 5-aza-2-deoxycytidine and 4-phenylbutyric acid
microRNA expression profiling in gastric cancer cells after 5-aza-2'-deoxycytidine (5-Aza-CdR) and 4-phenylbutyric acid (PBA) treatment was performed to investigate whether microRNA expression is controlled by these chromatin modifying drugs.
ORGANISM(S): Homo sapiens 
2008-10-10 | E-MEXP-1820 | biostudies-arrayexpress
ProteomicsMining potential serum biomarkers for gastric adenocarcinoma using quantitative proteomics
Serum is a valuable body fluid to diagnose cancer as it can be accessed with minimal invasive techniques. Studying the cancer serum proteome provides valuable insights into the pathophysiology of tumor progression. Gastric adenocarcinoma is an aggressive cancer resulting in poor prognosis, mainly du...
ORGANISM(S): Homo sapiens (Human) 
2015-07-27 | PXD001265 | Pride
Serum biomarkers Gastric cancer Quantitative proteomics Adenocarcinoma 
TranscriptomicsGalectin-3 regulates the expression of various genes in human gastric cancer cells
Although galectin-3 is known to modulate the cell proliferation, RNA processing, tumorigenesis, metastasis and apoptosis and also, which is highly expressed in human cancers, the function of galectin-3 is still controversy in gastric cancer. Here, we demonstrated the function of galectin-3 on gastri...
ORGANISM(S): Homo sapiens 
2011-05-31 | E-GEOD-29630 | biostudies-arrayexpress
ProteomicsHuman milk and gastric peptidomics
It is unclear to what degree protein degradation occurs in the infant stomach and whether peptides previously annotated for bioactivity are released. This study combined nanospray liquid chromatography separation with time of flight mass spectrometry, comprehensive structural libraries and informati...
ORGANISM(S): Homo sapiens (Human) 
2014-04-15 | PXD000688 | Pride
Peptidomics Human milk 
TranscriptomicsGene expression profiling of gastric cells infected by Helicobacter pylori
Helicobacter pylori are gram-negative bacteria that colonize the human stomach and are the major etiological factor in gastric carcinoma development. The aim of this work was to evaluate changes in gene expression in gastric cells induced by H. pylori. The human gastric carcinoma-derived cell line A...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-70394 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human gastric cancer cells after treatment with 5-aza-2-deoxycytidine and 4-phenylbutyric acid
Gene expression profiling in human gastric cancer cells after 5-aza-2'-deoxycytidine (5-Aza-CdR) and 4-phenylbutyric acid (PBA) treatment was analyzed to investigate what genes are controlled by these chromatin modifying drug
ORGANISM(S): Homo sapiens 
2008-10-09 | E-MEXP-1821 | biostudies-arrayexpress
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