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TranscriptomicsTranscription profiling of Gata3 conditional knock out mice to investigate epidermis and hair follicle differentiation
Transcriptome analysis on Gata3 conditional knock out murine hair follicles. Background. The transcription factor Gata3 is critically involved in epidermis and hair follicle differentiation. Yet, little is known about how Gata3 co-ordinates stem cell lineage determination in skin, which processes ar...
ORGANISM(S): Mus musculus 
2007-01-01 | E-MEXP-634 | biostudies-arrayexpress
GenomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-40129 | biostudies-arrayexpress
GenomicsGenome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types
We report genome-wide characterization of GATA3 binding sites in eleven well-defined developmental and effector cell types of the T lymphocyte lineage. By utilizing a conditional allele of GATA3, we investigated the impact of GATA3 expression on the mRNA expression patterns in several of these cell...
ORGANISM(S): Mus musculus 
2011-08-26 | E-GEOD-20898 | biostudies-arrayexpress
TranscriptomicsThe transcription factor GATA3 is critical for the development of all IL-7Ra-expressing innate lymphoid cells (ILCs) and maintenance of type 2 ILCs
Innate lymphoid cells (ILCs) play critical roles during innate immune responses to pathogens and lymphoid organ development. IL-7Ra+ ILC subsets, similar to T helper (Th) cell subsets, produce distinctive effector cytokines. The molecular control of IL-7Ra+ ILC development and maintenance has yet to...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-47851 | biostudies-arrayexpress
GenomicsBreast tumor specific mutation in GATA3 impacts protein stability and genomic location
The transcription factor GATA3 is a favorable prognostic indicator in estrogen receptor-M-NM-1 (ERM-NM-1)-positive breast tumors in which it participates with ERa and FOXA1 in a complex transcriptional regulatory program driving tumor growth. Paradoxically, GATA3 mutations are frequent in breast can...
ORGANISM(S): Homo sapiens 
2014-04-01 | E-GEOD-51274 | biostudies-arrayexpress
TranscriptomicsGATA3 acts upstream of FOXA1 in mediating ER binding by shaping enhancer accessibility
Estrogen Receptor (ESR1) drives growth in the majority of human breast cancers by binding to regulatory elements and inducing transcription events that promote tumor growth. Differences in enhancer occupancy by ESR1, contribute to the diverse expression profiles and clinical outcome observed in brea...
ORGANISM(S): Homo sapiens 
2012-11-26 | E-GEOD-39623 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of Gata3 [ChIP-seq and RNA-seq]
Shh and its receptor Ptch1 define two adjacent mutually exclusive domains: Shh+Ptch1- and Shh-Ptch1+ of E11.5 mouse brain. Gata3 ChIP-seq experiments and RNA-seq assays on Gata3-knockdown cells revealed that Gata3 up-regulates genes enriched in Shh-Ptch1+ domain. Our work is the first genome-wide ch...
ORGANISM(S): Rattus norvegicus 
2013-11-30 | E-MTAB-2008 | biostudies-arrayexpress
TranscriptomicsExpression of Cdx2 or Gata3 in R1 mouse embryonic stem cells
To identify whether Cdx2 or Gata3 can activate trophoblast specific gene expression when expressed in R1 ES cells. To assess the dependency of Gata3 activity on Cdx2, Gata3 was also expressed in Cdx2-null ES cells. Keywords: gene expression a fusion construct of either Cdx2 or Gata3 and the tamoxif...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12986 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis reveals unique regulation of transcription of Th2-specific genes by GATA3
Differentiation of naive CD4 T cells into type 2 helper (Th2) cells is accompanied by chromatin remodeling and increased expression of a set of Th2-specific genes including those encoding Th2 cytokines. IL-4-mediated STAT6 activation induces high levels of transcription of GATA3, a master regulator...
ORGANISM(S): Mus musculus 
2011-03-31 | E-GEOD-28292 | biostudies-arrayexpress
TranscriptomicsGata3 acts alongside Cdx2 to promote trophoblast gene expression downstream of Tead4 during mouse development
The first lineage decisions during mouse development lead to establishment of embryonic and extraembryonic tissues. The transcription factor Cdx2 plays a central role by repressing pluripotency genes, such as Oct4 and promoting trophoblast fate at the blastocyst stage. Here we show that the transcri...
ORGANISM(S): Mus musculus 
2010-02-21 | E-GEOD-12999 | biostudies-arrayexpress
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