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TranscriptomicsRegulation of nucleosome landscape and transcription factor binding at enhancers by BRG1
Enhancers of transcription activate transcription via binding of sequence-specific transcription factors to their target sites in chromatin. In this report, we identify GATA1-bound enhancers genome-wide and find a global reorganization of the nucleosomes at these enhancers during differentiation of ...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-26501 | biostudies-arrayexpress
TranscriptomicsPmel CD8+ stim 1 vs. stim 2
Repeat experiments of CD8+ pmel effector cells following one and two rounds of restimulation
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2348 | biostudies-arrayexpress
TranscriptomicsMurine CD8+ Pmel Lymphocytes IL-2 vs. IL-15
Central memory tumor-reactive CD8+ T cells confer superior antitumor immunity compared to effector memory T cells
ORGANISM(S): Mus musculus 
2010-06-10 | E-GEOD-2578 | biostudies-arrayexpress
TranscriptomicsGeneration of clinical grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of B-cell malignancies
Long-lived, self-renewing, multipotent T memory stem cells (TSCM) can trigger profound and sustained tumor regression but their rareness poses a major hurdle to their clinical application. Presently, clinically compliant procedures to generate relevant numbers of this T cell population are undefined...
ORGANISM(S): Homo sapiens 
2016-06-29 | E-GEOD-68003 | biostudies-arrayexpress
TranscriptomicsExpression data analyzing ID3 (Inhibitor of DNA binding 3)-affected mouse T cells
Mouse CD8+ T cells affected by ID3 (Inhibitor of DNA binding 3) display patterns of gene expression suggesting enhanced persistance and survival. In this study, we identified genes differentially expressed between ID32a transduced and mock transduced, and ID32a knockout and wild type mouse CD8+ T ce...
ORGANISM(S): Mus musculus 
2011-10-15 | E-GEOD-23568 | biostudies-arrayexpress
TranscriptomicsExpression data from human naïve (TN), stem cell memory (TSCM), central memory (TCM) and effector memory (TEM) CD8+ T cells
An early-differentiated CD8+ memory T cell subset with stem cell-like properties (TSCM) can be identified within the naïve-like T cell population by the expression of CD95/Fas. Based on experiments including exon- and gene-level expression analysis, we provide evidence that this subset of antigen-sp...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-23321 | biostudies-arrayexpress
TranscriptomicsCD8+ T-cell memory bears the transcriptional imprint of progressive differentiation
The generation of CD8+ T-cell memory is an important aim of immunization. While several distinct subsets of CD8+ T-cell memory have been described, the lineage relationships between effector (EFF), effector memory (EM) and central memory (CM) T cells remain contentious. Specifically, there is contra...
ORGANISM(S): Mus musculus 
2013-08-01 | E-GEOD-42459 | biostudies-arrayexpress
TranscriptomicsT cell oxygen-sensing proteins establish an immunologically tolerant metastatic niche
Cancer cells must evade immune responses at distant sites to establish metastases. The lung is a frequent site for metastasis. We hypothesized that lung-specific immunoregulatory mechanisms create an immunologically permissive environment for tumor colonization. We found that T cell-intrinsic expres...
ORGANISM(S): Mus musculus 
2016-08-03 | E-GEOD-85131 | biostudies-arrayexpress
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