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TranscriptomicsTranscriptional Profiling Defines the Roles of ERK and p38 Kinases in Epidermal Keratinocytes
Epidermal keratinocytes respond to extracellular influences by activating cytoplasmic signal transduction pathways that change the transcriptional profiles of affected cells. To define responses to two such pathways, p38 and ERK, we used SB203580 and PD98059 as specific inhibitors, and identified th...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50591 | biostudies-arrayexpress
TranscriptomicsEpidermal differentiation: basal vs. suprabasal keratinocytes
In epidermal differentiation basal keratinocytes detach from the basement membrane, stop proliferating, and express a new set of structural proteins and enzymes, which results in an impermeable protein/lipid barrier that protects us. To define the transcriptional changes essential for this process, ...
ORGANISM(S): Homo sapiens 
2010-12-15 | E-GEOD-26059 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series of cultured human keratinocytes treated with TNFalpha in the presence or absence of the NFkB inhibitor parthenolide
Cultured keratinocytes treated with TNFa in the presence or absence of NFkB inhibitor; time course 1, 4, 24 & 48 hrs.
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-2489 | biostudies-arrayexpress
TranscriptomicsTRANSCRIPTIONAL EFFECTS OF INHIBITING EGFR IN KERATINOCYTES
EGFR activation is important in human epithelial malignancies, including cutaneous squamous cell carcinoma, lung, colon, pancreatic and other cancers. Therapies targeting EGFR are currently used to treat such cancers, but one significant drawback to EGFR inhibitor therapies is the associated skin to...
ORGANISM(S): Homo sapiens 
2012-10-19 | E-GEOD-41680 | biostudies-arrayexpress
no omics definedTranscription profiling of human keratinocytes treated with JNK inhibitor vs. control reveals inhibition of JNK in keratinocyte cultures in vitro induces virtually all aspects of epidermal differentiation in vivo
In inflamed tissue, normal signal transduction pathways are altered by extracellular signals. For example, the JNK pathway is activated in psoriatic skin, which makes it an attractive target for treatment. To define comprehensively the JNK-regulated genes in human epidermal keratinocytes, we compare...
ORGANISM(S): Homo sapiens 
2007-10-26 | E-GEOD-4828 | biostudies-arrayexpress
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