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MetabolomicsIsotopomer analysis of MCF-7 breast cancer cell line incubated with 13C labelled glucose (GC-MS assay)
MS and NMR are two of the most powerful spectroscopic techniques used in the field of fluxomics, to analyze the flux distributions in cellular metabolomic pathways. Both of them possess pros and cons, such as, MS being the most sensitive and low-cost technique, while needs extensive sample processin...
2018-05-02 | MTBLS182 | MetaboLights
GenomicsTranscriptomic analysis of GC7- and Mock-treated mouse CD8 cytotoxic T cells
Transcriptomic analysis of GC7- and Mock-treated mouse CD8 cytotoxic T cells
PRJNA713789 | ENA
GenomicsThe eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
The eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
PRJNA1021181 | ENA
ProteomicsProteomic analysis of GC7-treated senescent and proliferating BJ fibroblasts
Quantitative analysis of global proteomic changes in proliferating and senescent BJ fibroblasts, treated with eIF5A hypusination inhibitor GC7 (10 uM) for 12h.
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD034251 | Pride
Gc7 Eif5a hypusination 
GenomicsRibosome profiling of GC7/vehicle-treated mouse primary B cells
Ribosome profiling of GC7/vehicle-treated mouse primary B cells
PRJNA553160 | ENA
ProteomicsNascent proteome analysis of proliferating and senescent BJ fibroblast treated with GC7
Analysis of proteomic changes in proliferating and senescent BJ fibroblast treated with eIF5A hypusination inhibitor GC7 for 12h.
ORGANISM(S): Homo sapiens (Human) 
2024-07-12 | PXD034334 | Pride
Gc7 Eif5a hypusination Nascent proteome 
OtherThe eIF5A hypusination inhibitor GC7 acts as a mitochondrial stress inducer
The eukaryotic translation factor eIF5A plays an essential role in translation elongation, especially across stretches of prolines and charged amino acids, and in translation termination. Although eIF5A is subjected to hypusination, a post-translational modification unique to this protein, how hypus...
ORGANISM(S): Homo sapiens 
2024-03-31 | GSE244063 | GEO
OtherRibosome profiling of GC7/vehicle-treated mouse primary B cells
Mouse primary B cells were treated with 10 uM GC7 or vehicle control and processed for ribosome profiling. During harvesting, samples were spiked with S. cerevisiae lysate containing stable polysomes.
ORGANISM(S): Mus musculus 
2019-07-09 | GSE133934 | GEO
UnknownOpposite effects of spermidine and GC7 in cell culture are dictated by distinct molecular targets.
Not available
S-EPMC12802350 | biostudies-literature
UnknownInsights Into the Binding Mechanism of GC7 to Deoxyhypusine Synthase in Sulfolobus solfataricus: A Thermophilic Model for the Design of New Hypusination Inhibitors.
Not available
S-EPMC7773846 | biostudies-literature
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