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GenomicsEffect of liver-specific deletion of Gclc, Nrf2, and Gclc-Nrf2 on the liver
Effect of liver-specific deletion of Gclc, Nrf2, and Gclc-Nrf2 on the liver
PRJNA1095885 | ENA
GenomicsEffect of whole-body deletion of Gclc on the liver
Effect of whole-body deletion of Gclc on the liver
PRJNA1096112 | ENA
TranscriptomicsEffect of liver-specific deletion of Gclc, Nrf2, and Gclc-Nrf2 on the liver
The rate-limiting step in glutathione (GSH) synthesis is controlled by glutamate-cysteine ligase catalytic subunit. GSH is reported to buffer oxidative stress. In the absence of GSH, the antioxidant transcription factor Nrf2 is reported to be stabilized. The liver has the highest levels of GSH, but ...
ORGANISM(S): Mus musculus 
2024-05-29 | GSE263119 | GEO
GenomicsA GCLC Inhibitor Enhances the Antitumor Efficacy of Glutathione Metabolic Pathway Inhibition in SMARCB1-Deficient Rhabdoid Tumors
A GCLC Inhibitor Enhances the Antitumor Efficacy of Glutathione Metabolic Pathway Inhibition in SMARCB1-Deficient Rhabdoid Tumors
PRJNA1406303 | ENA
ProteomicsGlutathione supports lipid abundance in vivo
Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many diseases, but the requirement for GSH in adult tissues is uncle...
ORGANISM(S): Mus musculus (Mouse) 
2024-06-03 | PXD052674 | Pride
Mouse Glutathione Gclc Liver Nrf2 
TranscriptomicsA GCLC Inhibitor Enhances the Antitumor Efficacy of Glutathione Metabolic Pathway Inhibition in SMARCB1-Deficient Rhabdoid Tumors
Malignant rhabdoid tumors and epithelioid sarcomas, characterized by SMARCB1 deficiency, are aggressive cancers with limited effective treatments, necessitating development of therapeutic strategies. This study investigated the therapeutic efficacy and mechanism of action of inhibitors targeting glu...
ORGANISM(S): Homo sapiens 
2026-02-11 | GSE317224 | GEO
UnknownGCLC desuccinylation regulated by oxidative stress protects human cancer cells from ferroptosis.
Not available
S-EPMC12432198 | biostudies-literature
UnknownGclc deficiency in mouse CNS causes mitochondrial damage and neurodegeneration.
Not available
S-EPMC6075078 | biostudies-literature
TranscriptomicsEffect of whole-body deletion of Gclc on the liver
The rate-limiting step in glutathione (GSH) synthesis is controlled by glutamate-cysteine ligase catalytic subunit. To investigate the impact of GSH in vivo, we induced a deletion of Gclc using a Gclcf/f Rosa26-CreERT2 mouse model and harvested liver tissue for analysis.
ORGANISM(S): Mus musculus 
2024-05-29 | GSE263190 | GEO
UnknownNSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis.
Not available
S-EPMC11750563 | biostudies-literature
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