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TranscriptomicsDiscovery of the genes controlled by the second messenger cyclic di-GMP in Mycobacterium tuberculosis
Cyclic di-GMP (c-di-GMP) is a ubiquitous second messenger that regulates many biological processes in bacteria. The genome in Mycobacterium tuberculosis encodes a single copy of the diguanylate cyclase gene (dgc) responsible for c-di-GMP synthesis. To determine the role of c-di-GMP signaling in M. t...
ORGANISM(S): Mycobacterium tuberculosis 
2013-10-09 | E-GEOD-37973 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of di-n-butyl phthalate and 17α ethinyl-oestradiol responses in three-spined stickleback testes
The data comes from a study, where three-spined sticklebacks (Gasterosteus aculeatus) were exposed to di-n-butyl phthalate (DBP) and 17α ethinyl-oestradiol (EE2) at nominal concentrations 35 μg/L and 40 ng/L, respectively, for four days. The aim of the study was to obtain insight into the acute tran...
ORGANISM(S): Gasterosteus aculeatus 
2015-10-10 | E-MTAB-3951 | biostudies-arrayexpress
TranscriptomicsAge and albumin D site-binding protein control tissue plasminogen activator levels: neurotoxic impact.
Recombinant tissue-type plasminogen activator (tPA) is the fibrinolytic drug of choice to treat stroke patients. However, a growing body of evidence indicates that besides its beneficial thrombolytic role, tPA can also have a deleterious effect on the ischaemic brain. Although ageing influences stro...
ORGANISM(S): Mus musculus 
2009-08-23 | E-GEOD-9004 | biostudies-arrayexpress
MetabolomicsImprovement of prediction ability by integrating multi-omic datasets in barley

BACKGROUND: Genomic prediction (GP) based on single nucleotide polymorphisms (SNP) has become a broadly used tool to increase the gain of selection in plant breeding. However, using predictors that are biologically closer to the phenotypes such as transcriptome and metabolome may...

2022-03-18 | MTBLS1561 | MetaboLights
UnknownGe<sub>5</sub> Clusters in the Trivalent Rare-Earth Compound Sm<sub>3</sub>Ge<sub>5</sub>.
Not available
S-EPMC12486209 | biostudies-literature
ProteomicsStructural basis for the c-di-AMP - dependent regulation of the stringent response by DarB
The bacterial second messenger c-di-AMP controls various cellular processes including potassium and osmolyte homeostasis. The c-di-AMP receptor protein DarB of Bacillus subtilis binds to the Rel protein and triggers the Rel-dependent stringent response. Here we report crystal structures of DarB in t...
ORGANISM(S): Bacillus subtilis subsp. subtilis 
2022-08-12 | PXD033346 | Pride
Cx-ms Bs3 Darb 
TranscriptomicsThe scr circuit in Vibrio parahaemolyticus: output targets and transcriptional regulation by a c-di-GMP responsive protein
Vibrio parahaemolyticus scr genes modulate expression of gene sets pertinent to swarming and biofilm formation. They do so by affecting the level of the second messenger c-di-GMP. Here we explore the extent of this regulation by comparing the transcriptomes of a scrABC mutant and its wild-type paren...
ORGANISM(S): Vibrio parahaemolyticus 
2011-12-31 | E-GEOD-30508 | biostudies-arrayexpress
UnknownScanning X-ray strain microscopy of inhomogeneously strained Ge micro-bridges.
Not available
S-EPMC3874020 | biostudies-literature
TranscriptomicsRNAseq analysis of IKKbeta knockdown EDC4 knockdown irradiated and untreated
U2OS cells expressing DOX inducible pTRIPZ shRNA against IKKbeta or EDC4 were irradiated or left untreated. RNA stability was determined as through actinomycin D chase experiment.
ORGANISM(S): Homo sapiens 
2018-10-29 | E-MTAB-7199 | biostudies-arrayexpress
UnknownStrong hole-photon coupling in planar Ge for probing charge degree and strongly correlated states.
Not available
S-EPMC11585541 | biostudies-literature
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