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TranscriptomicsIntegrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma: MSX1
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic pla...
ORGANISM(S): Homo sapiens 
2014-05-28 | E-GEOD-16481 | biostudies-arrayexpress
TranscriptomicsIntegrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma: MEIS1
The pediatric tumor neuroblastoma is the second cause of cancer-related death in children. Although several recurrent gene aberrations have been found, the main signaling networks in the neuroblastoma cell, that can give important clues for more specific, more efficient treatment, is still unknown. ...
ORGANISM(S): Homo sapiens 
2012-09-24 | E-GEOD-17827 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HED293 cells with GFP constructs at different genomic positions are expressed corresponding to the activity of the domains of integration
Transcription factor complexes bind to regulatory sequences of genes, providing a system of individual expression regulation. Targets of distinct transcription factors usually map throughout the genome, without clustering. Nevertheless, highly and weakly expressed genes do cluster in separate chromo...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6629 | biostudies-arrayexpress
TranscriptomicsEZH2 over-expression is associated with gain of chromosome arm 7q and essential for cell cycle progression and a marker of poor prognosis in neuroblastoma
Neuroblastoma is an often aggressive childhood cancer with several large chromosomal regions showing recurrent gains or losses. Chromosome 7q is gained in 40-60% of neuroblastomas, but despite being the second most frequent genomic aberration, no oncogenes have been linked to 7q gain. We performed e...
ORGANISM(S): Homo sapiens 
2013-10-06 | E-GEOD-28409 | biostudies-arrayexpress
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