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TranscriptomicsExpression profiling of HCC
61 human HCCs were analyzed for genome-wide gene expression. Samples were collected at two sites in Germany, Heidelberg (HD) and Hannover (N). The Heidelberg Collection include 40 independent HCC: 19 liver resections and 17 explant liver specimen (4 not determined); median age at surgery was 57 year...
ORGANISM(S): Homo sapiens 
2013-09-05 | E-GEOD-50579 | biostudies-arrayexpress
TranscriptomicsGene expression profile of decidual macrophages and different in vitro M1 and M2 macrophage populations
Uterine (decidual) macrophages (M) are believed to play an important role in fetal tolerance during pregnancy, but the factors that regulate them are not known. In this study we investigated the potential role of several factors (M-CSF, GM-CSF, IL-4/13, IL-10, progesterone and estradiol) to drive th...
ORGANISM(S): Homo sapiens 
2011-11-22 | E-GEOD-30595 | biostudies-arrayexpress
TranscriptomicsPax6 mutant neocortex vs. wild type
Pax6 is a transcription factor with key functional roles in embryonic development. In order to identify downstream effectors of Pax6 in the developing cerebral cortex we performed microarray analysis. We compared gene expression profiles of cortical tissues isolated from wild type and Pax6-/- mouse ...
ORGANISM(S): Mus musculus 
2011-10-31 | E-GEOD-32271 | biostudies-arrayexpress
TranscriptomicsCAL-51 breast cancer side population cells
Human solid tumors contain rare cancer side population (SP) cells, which expel the fluorescencent dye H33342 and display cancer stem cell characteristics. Transcriptional profiling of cancer SP cells isolated by H33342 fluorescence analysis is a newly emerging approach to discover cancer stem cell m...
ORGANISM(S): Homo sapiens 
2009-12-31 | E-GEOD-18773 | biostudies-arrayexpress
TranscriptomicsHepatic gene expression during the development of experimental biliary atresia in different mouse strains
Biliary atresia (BA) is a rare cholestatic disease of unknown etiology that affects infants and shows an incidence of 1 out of 18,000 live births in Europe (1). The first therapeutic option is a timely performed portoenterostomy. However, the majority of patients suffer from a progressive inflammato...
ORGANISM(S): Mus musculus 
2009-08-30 | E-GEOD-13245 | biostudies-arrayexpress
TranscriptomicsEarly-induced genes of human regulatory CD4+CD25hi Treg and CD4+CD25- Th cells
Goals and objectives of this study: to identify genes preferentially induced in human CD4+CD25hi Treg cells following T-cell activation with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, comparative gene expressio...
ORGANISM(S): Homo sapiens 
2009-04-20 | E-GEOD-13017 | biostudies-arrayexpress
TranscriptomicsMast cells in response to some pathogens elicit a transcriptional program devoid of type I IFN response
Although mast cells elicit proinflammatory and type I IFN responses upon VSV infection, in response to L.monocytogenes (L.m) or S. Typhimurium (S.t), such cells elicit a transcriptional program devoid of type I IFN response. Balanced induction of proinflamatory and type I interferon (IFN) response...
ORGANISM(S): Mus musculus 
2009-12-31 | E-GEOD-18500 | biostudies-arrayexpress
TranscriptomicsHuman activated Treg cells and retrovirally engineered Th cells, transduced with GARP, FOXP3 or control GFP vector
Goals and objectives of this study: to identify genes of the Treg signature induced by consitutive expression of GARP or FOXP3 in antigen-specific Th cells with potential role for stabililization & maintenance of the regulatory program. Keywords: T-cell receptor stimulation, gene-regulation, compar...
ORGANISM(S): Homo sapiens 
2009-04-20 | E-GEOD-13234 | biostudies-arrayexpress
TranscriptomicsProfiling of p53-responsive genes in human breast cancer cells harboring endogenous ts-p53 E285K
The ts-p53 E285K protein is a rare p53 mutant with temperature-sensitive (ts) loss of function characteristics. In cancer cells, which express ts-p53 E285K intrinsically, endogenous wild type p53 activity is reconstituted by appropriate cultivation temperature (permissive condition). At non-appropri...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35006 | biostudies-arrayexpress
TranscriptomicsIFN alpha-induced gene expression in human NK cells
NK cells are believed to contribute to the control of hepatitis C virus infection and pathogenesis of liver disease. Standard treatment of both acute and chronic hepatitis C is based on the administration of interferon alpha, however, the effects of type I interferons on human NK cells have not been...
ORGANISM(S): Homo sapiens 
2010-08-18 | E-GEOD-15743 | biostudies-arrayexpress
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