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TranscriptomicsGene expression and gene ontology analysis of the transcriptional changes occurring in spinal cord from the G93A SOD1 gene mutant rat
We have investigated the process of disease-induced functional perturbation and the related transcriptional changes occurring in thoraco-lumbar spinal cord extracted from Sprague-Dawley rats heterozygous for the G93A SOD1 gene mutation (Emerging Model 2148 Het Male, Taconic USA; Wyeth and Amyotrophi...
ORGANISM(S): Rattus norvegicus 
2010-06-23 | E-GEOD-20894 | biostudies-arrayexpress
TranscriptomicsMouse ES-derived motor neurons (ES-MN) exposed to SOD1 mutant mouse astrocyte conditioned media
This datased was used to obtain a genome-wide expression signature for the early response of mouse motor neurons to mutant SOD1 astrocytes conditioned media. Neurons, far from living in isolation, are surrounded by a host of other neuronal and non-neuronal cells, such as astrocytes. The latter enter...
ORGANISM(S): Mus musculus 
2014-12-17 | E-GEOD-49023 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of retinae from wildtype and retinoschisin knockout mice (Rs1h-/Y) at postnatal day 7 to understand the effect of retinoschisin on gene expression
Genome-wide expression profiling of the retinoschisin deficient retina in C57CL/6 mice. Experiment Overall Design: RNAs from retinae from 3 Wildtype Mice versus 3 Retinoschisin-KO mice (Rs1h-/Y) at postnatal day 7 (P7) were hybridized onto Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-5581 | biostudies-arrayexpress
TranscriptomicsCommon neuroinflammatory pathways in neurodegenerative diseases
Neurodegenerative diseases of the central nervous system are characterised by pathogenetic cellular and molecular changes in specific areas of the brain that lead to the dysfunction and/or loss of explicit neuronal populations. Despite exhibiting different clinical profiles and selective neuronal lo...
ORGANISM(S): Homo sapiens 
2011-01-29 | E-GEOD-26927 | biostudies-arrayexpress
ProteomicsNeuroLINCS Proteomics: Defining human-derived iPSC proteomes and protein signatures of pluripotency
The National Institute of Health (NIH) Library of integrated network-based cellular signatures (LINCS) program is premised on generation of a publicly available data resource composed of cell-based biochemical responses or “signatures” to genetic or environmental perturbations. The NeuroLINCS center...
ORGANISM(S): Homo Sapiens 
2020-09-15 | PXD021497 | panorama
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