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TranscriptomicsDifferentiation and specification of resident tissue macrophages [SMART-Seq2]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81686 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [ID3-KO RNA-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-83854 | biostudies-arrayexpress
TranscriptomicsDifferentiation and specification of resident tissue macrophages [MARS-seq]
Tissue resident macrophages are functionally diverse cells that share an embryonic mesodermal origin. However, the mechanism(s) that control their specification remain unclear. We performed transcriptional, molecular and in situ spatio-temporal analyses of macrophage development in mice. We report t...
ORGANISM(S): Mus musculus 
2016-08-08 | E-GEOD-81760 | biostudies-arrayexpress
TranscriptomicsResponse of IRF7-deficient peripheral blood mononuclear cells to pH1N1 influenza virus infection
IRF7 plays a critical role in the production and amplification of the antiviral type I and III interferon response. Autosomal recessive IRF7-deficiency resulted in life-threatening influenza disease in a 3-year-old child. We studied the impact of IRF7-deficiency in non-hematopoietic tissues (fibrobl...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-66486 | biostudies-arrayexpress
TranscriptomicsComplete TLR3 deficiency
The objective of this study is to study the Toll-like receptor 3 (TLR3)-dependent gene expression in human fibroblast cells and peripheral blood mononuclear cells (PBMCs) Fibroblast cells and PBMCs from donors with autosomal recessive (AR) complete TLR3 deficiency and autosomal dominant (AD) partial...
ORGANISM(S): Homo sapiens 
2011-11-02 | E-GEOD-30951 | biostudies-arrayexpress
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