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MetabolomicsSequential lipidomic, metabolomic, and proteomic analyses of serum, liver, and heart tissue specimens from peroxisomal biogenesis factor 11α knockout mice
Peroxisomes are versatile single membrane-enclosed cytoplasmic organelles, involved in reactive oxygen species (ROS) and lipid metabolism and diverse other metabolic processes. Peroxisomal disorders result from mutations in Pex genes-encoded proteins named peroxins (PEX proteins) and single peroxiso...
2022-02-02 | MTBLS1887 | MetaboLights
MetabolomicsLactiplantibacillus plantarum PS128 restores microbiota-driven polyamine homeostasis to alleviate autism-like behaviors in Fmr1 knockout mice

Background: Autism spectrum disorder (ASD) is biologically heterogeneous and has limited mechanism-informed interventions targeting core behavioral symptoms. Emerging evidence suggests that gut microbial metabolism shapes neurobehavioral outcomes, yet the specific metabolic pathw...

2026-02-10 | MTBLS13881 | MetaboLights
MetabolomicsMetabolic Biomarkers of Ageing in C57BL/6J Wild-Type and Flavin-Containing Monooxygenase 5 (FMO5)-Knockout Mice
It was recently demonstrated in mice that knockout of the flavin-containing monooxygenase 5 gene, Fmo5, slows metabolic ageing via pleiotropic effects. We have now used an NMR-based metabonomics approach to study the effects of ageing directly on the metabolic profiles of urine and plasma from male,...
2018-06-20 | MTBLS667 | MetaboLights
MetabolomicsTubular insulin-induced gene 1 deficiency promotes NAD+ consumption and exacerbates kidney fibrosis

Profibrotic proximal tubular (PT) were identified as a unique phenotype of PTCs in renal fibrosis by single-cell RNA sequencing (scRNA-seq). Controlling the process of renal fibrosis requires understanding how to manage the S1 subset's branch to the S3 subset rather than to the profibrotic PT sub...

2024-05-28 | MTBLS9985 | MetaboLights
ProteomicsDIA-Brain-aged- target gene knockout mice
The differences between wild-type mice and target gene knockout mice were analyzed by proteomic tests.
ORGANISM(S): Mus Musculus 
2025-01-13 | PXD059745 |
TranscriptomicsRNAseq on lungs from WT vs claudin 4 KO mice that underwent ventilator-induced lung injury
WT mice and claudin 4 KO mice were exposed to ventilator-induced lung injury (VILI) for 2 hours. We found that in some Cldn4 KO mice, injury was similar to WT, while in others, injury was higher, as assessed by amount of protein leak into broncho-alveolar lavage fluid. We performed RNAseq to find wh...
ORGANISM(S): Mus musculus 
2014-11-04 | E-GEOD-50927 | biostudies-arrayexpress
ProteomicsProteomes of ZIP8-wildtype and ZIP8-KO HeLa cell lines
The human ZRT/IRT-like protein 8 (ZIP8), encoded by the solute carrier family 39 member 8 gene SLC39A8, is a metal cation symporter located mainly on the cell membrane. ZIP8 is well-known for its role in transporting divalent metal ions into the cells – these ions include several essential micronutr...
ORGANISM(S): Homo sapiens (Human) 
2022-10-20 | PXD036680 | Pride
Single-gene knockout-coupled omics Slc39a8 Hela cell line Zip8 Itraq 
TranscriptomicsTranscription profiling of mouse fundic mucosa in the presence/absence of gastrin and in gastrin-CCK double knockout mice
Fundic mucosa gene expression in wildtype vs gastrin knockout, gastrin replaced gastrin KO and gastrin-CCK double knockout mice; Fundic mucosal scraping RNA were isolated from WT, Gastrin Knockout, Gastrin replaced KO and Gastrin-CCK double knockout mice. Targets from three biological replicates of...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4810 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in the Pancreatic lymph node of Deaf1 knockout mice vs. wild type littermate controls
Gene expression in the the pancreatic lymph node of 4, 12, and 30 week old Deaf1-knockout (KO) mice compared to BALB/c littermate controls. Gene expression was measured in the pancreatic lymph nodes of 4 wk old Deaf1 KO mice (2 replicates), 12 wk old Deaf1-KO mice (3 replicates), and 30 wk old Deaf1...
ORGANISM(S): Mus musculus 
2011-08-31 | E-GEOD-29153 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of GPR86 (P2RY13) KO mice
The purinergic receptor P2Y13 (P2RY13) has been shown to play a role in the uptake of holo-HDL particles in in vitro hepatocyte experiments. In order to determine the role of P2Y13 in lipoprotein metabolism in vivo, we ablated the expression of this gene in mice and found that P2Y13 knockout mice ha...
ORGANISM(S): Mus musculus 
2010-09-10 | E-GEOD-20920 | biostudies-arrayexpress
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