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ProteomicsThe Functions of the COPII Gene Paralogs SEC23A and SEC23B Are Interchangeable In Vivo
This dataset includes BioID for SEC23A and SEC23B. The paper describes the functional redundancy of these two gene paralogs in the context of human disease.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-11-09 | MSV000081703 | MassIVE
ProteomicsDuplicated ribosomal protein paralogs promote alternative translation and drug resistance
Ribosomes are often seen as monolithic machines produced from uniformly regulated genes. However, in yeast most ribosomal proteins come from duplicated genes. Here, we demonstrate that gene duplication may serve as a stress-adaptation mechanism modulating the global proteome through the differential...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-08-09 | PXD033843 | Pride
Drpg Saccharomyces cerevisiae Paralogs 
TranscriptomicsNovel male-biased expression in paralogs of the aphid slilmfast nutrient amino acid transporter expansion
A major goal of molecular evolutionary biology is to understand the fate and consequences of duplicated genes. In this context, aphids are particularly intriguing because the newly sequenced pea aphid genome is characterized by extraordinarily high levels of lineage-specific gene duplication relativ...
ORGANISM(S): Myzus persicae 
2011-09-13 | E-GEOD-31024 | biostudies-arrayexpress
ProteomicsParalog protein compensation preserves protein-protein interaction networks following gene loss cancer
Abstract Proteins operate within dense interconnected networks, where interactions are necessary both for stabilising proteins and enabling them to execute their molecular functions. Remarkably, the protein-protein interaction networks operating within tumour cells continue to function despite wide...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055643 | Pride
Protein-protein interaction Compensation Paralog protein Cancer. 
ProteomicsTRB-mediated epigenetic gene regulation is controlled by distinct regulatory complexes utilizing specialized TRB paralogs
Epigenetic regulators shape chromatin landscapes, allowing cells to express distinct gene sets depending on cell-type, developmental stage or environmental cues. These regulatory complexes rely on interactions with sequence-specific DNA binding proteins, such as the small family of TELOMERE REPEAT B...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2026-03-13 | PXD069673 | Pride
Polycomb repressive complex 2 (prc2) Telomere repeat binding factors (trbs) 
GenomicsActivating PAX Gene Family Paralogs to Complement PAX5 Leukemia Driver Mutations
Activating PAX Gene Family Paralogs to Complement PAX5 Leukemia Driver Mutations
PRJNA432203 | ENA
UnknownCRISPR/Cas9-induced gene conversion between ATAD3 paralogs.
Not available
S-EPMC8844715 | biostudies-literature
UnknownImpact of scaffolding protein TNRC6 paralogs on gene expression and splicing.
Not available
S-EPMC8370741 | biostudies-literature
GenomicsFunctional Diversification, Redundancy and Epistasis among Paralogs of the Drosophila melanogaster Obp50a-d Gene Cluster
Functional Diversification, Redundancy and Epistasis among Paralogs of the Drosophila melanogaster Obp50a-d Gene Cluster
PRJNA668758 | ENA
UnknownTissue-Specificity of Gene Expression Diverges Slowly between Orthologs, and Rapidly between Paralogs.
Not available
S-EPMC5193323 | biostudies-literature
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