Genetic code expansion

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xref:PubMed:36868209 (5)
xref:PubMed:37681286 (2)
xref:ArrayExpress:E-MTAB-3061 (1)
xref:PubMed:26727110 (1)

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Chimeric design of Pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion

An orthogonal aminoacyl-tRNA synthetase/tRNA pair is a key prerequisite for site-specific incorporation of unnatural amino acids. Due to its high codon suppression efficiency and full orthogonality, the pyrrolysyl-tRNA synthetase/pyrrolysyl-tRNA pair is currently the ideal system for genetic code ex...

ORGANISM(S): Escherichia coli

2020-05-25 | PXD018660 | Pride

Chimeric design Genetic code expansion

Genetic code expansion reveals site-specific lactylation in living cells reshapes protein function

ORGANISM(S): Homo Sapiens

2023-12-26 | PXD048127 |

Measuring the tolerance of the genetic code to altered codon size

Measurement of the amino acid incorporation of tRNAs engineered to decode four-base codons.

ORGANISM(S): Escherichia coli

2022-03-02 | PXD031925 | Pride

Synthetic biology Genetic code expansion

Genetic code expansion enables site-specific acetylation to reprogram Lunasin toward BRD4 targeting

Lunasin is a plant-derived peptide with moderate anticancer activity but has limited potency and undefined molecular targets. To enhance its functional properties, we developed a site-specifically acetylated variant (Lunasin-K29ac) via genetic code expansion. To characterize the molecular interactio...

ORGANISM(S): Homo Sapiens

2026-04-07 | PXD076719 |

Genetic Code Expansion in Animals.

Not available

S-EPMC7026698 | biostudies-literature

Genetic code expansion in the mouse brain.

Not available

S-EPMC5215917 | biostudies-literature

The central role of tRNA in genetic code expansion.

Not available

S-EPMC5603357 | biostudies-literature

Genetic Code Expansion of Vibrio natriegens.