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MetabolomicsEnterococcus faecalis readily adapts membrane phospholipid composition to environmental and genetic perturbation

The bacterial lipid membrane, consisting both of fatty acid (acyl) tails and polar head groups, responds to changing conditions through alteration of either the acyl tails and/or head groups. This plasticity is critical for cell survival as it allows maintenance of both the protective nature of t...

2021-05-17 | MTBLS2080 | MetaboLights
ProteomicsSample multiplexing-based targeted pathway proteomics with real-time analytics reveals the impact of genetic variation on protein expression
Targeted proteomics enables hypothesis-driven research by measuring the cellular expression of protein cohorts related by function, disease, or class after perturbation. Here, we present a pathway-centric approach and an assay builder resource for targeting entire pathways of proteins selected from ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2022-08-11 | MSV000090110 | MassIVE
ProteomicsStructural perturbation at the N-terminal domain of human phosphoglycerate kinase 1 reduces the kinetic stability and unfolding cooperativity of a two-domain enzyme
Phosphoglycerate kinase has been a model for the stability, folding cooperativity and catalysis of a two-domain protein. The human isoform 1 (hPGK1) is associated with cancer development and rare genetic diseases that affect several of their features. To investigate how mutations affect hPGK1 foldin...
ORGANISM(S): Homo sapiens (Human) 
2022-11-03 | PXD035628 | Pride
Protein folding  structural perturbation  disease 
UnknownA unified genetic perturbation language for human cellular programming.
Not available
S-EPMC12667873 | biostudies-literature
UnknownLeveraging drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans.
Not available
S-EPMC9892765 | biostudies-literature
TranscriptomicsStudy of the functional implication of altered nuclear morphology on global gene expression profile in Drosophila S2R+ cells
A probe of the coupling of gene expression and nuclear structure in Drosophila S2R+ cells was undertaken by a study of altered expression profile following a 6 day RNAi mediated genetic perturbation of Klaroid (CG18584), Lamin (CG6944) and Msp-300 (CG33715). Genotypic Technology designed Custom Ge...
ORGANISM(S): Drosophila melanogaster 
2012-10-01 | E-GEOD-32525 | biostudies-arrayexpress
UnknownGenetic screens in isogenic mammalian cell lines without single cell cloning.
Not available
S-EPMC7005275 | biostudies-literature
GenomicsBridging Genetic Perturbation and Niche Function
NicheXplorer Bridges Genetic Screening and Niche Engineering for Functional Microenvironment Discovery
PRJEB90556 | ENA
UnknownCryptic genetic variation of expression quantitative trait locus architecture revealed by genetic perturbation in Caenorhabditis elegans.
Not available
S-EPMC10151397 | biostudies-literature
TranscriptomicsTat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNAs by HIV-1
Herein expression trends of host miRNA were measured in CEMx174 lymphocytes infected with HIV-1NL4-3 or derivative strains deficient in Tat RSS activity (RSS) or vif-/vpr (VV), or unexposed to virus. As expected from previous studies, miRNA trends were different in naive and HIV-1 infected cells. ...
ORGANISM(S): Homo sapiens 
2011-03-01 | E-GEOD-21892 | biostudies-arrayexpress
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