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Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
Gene Expression Networks in the Drosophila Genetic Reference Panel
Extensive tissue-specific, circadian molecular variation in a Drosophila Genetic Reference Panel
Certain mouse strains have the ability to heal both ear wounds and knee articular cartilage injuries. A positive genetic correlation between cartilage healing and protection from osteoarthritis exists, which suggests that a common core of genes may operate in healing process. Here, we analyzed knee...
ORGANISM(S): Mus musculus 
We performed RNA sequencing of wing discs at the wandering L3 larval stage from 32 inbred lines of Drosophila genetic reference panel (DGRP) that consists of 16 big and 16 small wing lines. We aimed to understand system-wide gene regulatory mechanisms that attain the observed natural variation in wi...
ORGANISM(S): Drosophila melanogaster 
A major challenge of modern biology is to understand how naturally occurring variation in DNA sequences affects complex organismal phenotypes through networks of intermediate molecular phenotypes. Here, we performed deep RNA sequencing of 200 Drosophila Genetic Reference Panel inbred lines with comp...
ORGANISM(S): Drosophila melanogaster 
2020-02-28 | GSE117850 | GEO
We report a large-scale transcriptomic analysis of several tissues of a reference Drosophila melanogaster strain as well as 141 Drosophila Genetic Reference Panel (DGRP) lines at high temporal resolution. Comprehensive data analysis has identified thousands of genes under clock- and tissue-specific ...
ORGANISM(S): Drosophila melanogaster 
2020-12-10 | GSE126018 | GEO
The Drosophila melanogaster Genetic Reference Panel
Our primary objective was to characterize the amount of variation in transcript abundance among individual flies with identical genotypes. We also wanted to determine which analysis methods would be optimal for RNA-Seq data. To meet these objectives, we performed transcriptional profiling of whole...
ORGANISM(S): Drosophila melanogaster 
Sequence data of the Tetranychus reference panel (Wybouw Lab)
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