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GenomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [RRBS]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-45341 | biostudies-arrayexpress
TranscriptomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer [Methylation profiling by array]
Genetic and epigenetic alterations are essential for the initiation and progression of human cancer. We previously reported that primary human medulloblastomas showed extensive cancer-specific CpG island DNA hypermethylation in critical developmental pathways. To determine whether genetically engine...
ORGANISM(S): Homo sapiens 
2013-10-10 | E-GEOD-45240 | biostudies-arrayexpress
TranscriptomicsGEMM CRC collection analysis
A collection of genetically engineered mouse models (GEMM) of colorectal cancer (CRC) were created, and primary tumors from these GEMMs were analyzed. Primary CRC tumors from these GEMMs were genotyped to confirm that they contain the core genetic lesions of interest, including APC, P53, KRAS, and B...
ORGANISM(S): Mus musculus 
2014-07-01 | E-GEOD-50794 | biostudies-arrayexpress
TranscriptomicsExpression data from genetically engineered mouse models (GEMMs)
3 Cell lines from Apc, p53 (AP) GEMMs were compared to 12 cell lines from Apc, Kras, p53 (AKP) GEMMs. Mouse 430 2.0 arrays were used to determine genomic expression differences between the two genotypes (AP and AKP). RNA was extracted from 3 AP and 10 AKP cell lines using the Qiagen RNEasy kit, and ...
ORGANISM(S): Mus musculus 
2013-07-02 | E-GEOD-39557 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Classification of Genetically Engineered Mouse Models of Breast Carcinoma Identifies Human Subtype Counterparts
Background: Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models (GEMMs) are useful resources for studying breast cancers in vivo under genetically controlled and immune competent conditions. Identifying murine models with cons...
ORGANISM(S): Mus musculus 
2013-11-04 | E-GEOD-42640 | biostudies-arrayexpress
GenomicsGenetically engineered mouse models and syngeneic graft models of bladder cancer
Genetically engineered mouse models and syngeneic graft models of bladder cancer
PRJNA1256787 | ENA
GenomicsFundamental differences in promoter CpG island DNA hypermethylation between human cancer and genetically engineered mouse models of cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-10-10 | E-GEOD-45342 | biostudies-arrayexpress
TranscriptomicsPredicting drug responsiveness in humans cancers using genetically engineered mice
Anti-cancer drug testing is challenging, but genetically engineered mouse models (GEMMs) and orthotopic, syngeneic transplants (OSTs) may offer advantages for pre-clinical testing including an intact microenvironment. We examined the efficacy of six chemotherapeutic or targeted anti-cancer drugs, al...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-37915 | biostudies-arrayexpress
GenomicsGenetically engineered mouse models of sarcoma using CRISPR/Cas9
Generation and comparison of CRISPR/Cas9 and Cre-mediated genetically engineered mouse models of sarcoma
PRJEB22279 | ENA
TranscriptomicsExpression data from genetically engineered mouse models (GEMMs)
3 Cell lines from Apc, p53 (AP) GEMMs were compared to 12 cell lines from Apc, Kras, p53 (AKP) GEMMs. Mouse 430 2.0 arrays were used to determine genomic expression differences between the two genotypes (AP and AKP).
ORGANISM(S): Mus musculus 
2013-07-02 | GSE39557 | GEO
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