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UnknownMolecular characterization and expression analysis of Hsp90 in Schizothorax prenanti.
Not available
S-EPMC5083668 | biostudies-literature
GenomicsRUNX1 is a key target gene in t(4;11) leukemias and contributes to gene activation by interacting with the AF4-MLL complex
The Mixed Lineage Leukemia 1 protein (MLL1) is an important epigenetic regulator required for the maintenance of gene activation during development. MLL1 chromosome translocations produce novel fusion proteins that cause aggressive leukemias in humans. Individual MLL1 fusion proteins have distinct l...
ORGANISM(S): Homo sapiens 
2013-01-31 | E-GEOD-42075 | biostudies-arrayexpress
TranscriptomicsDNA methylation signatures define molecular subtypes of Diffuse Large B Cell Lymphoma
We performed DNA methylation (HELP array) and gene expression profiling in 69 samples of diffuse large B cell lymphoma (DLBCL). First, by gene expression, two molecular subtypes of DLBCL termed as "germinal center B cell-like" (GCB) and "activated B cell-like" (ABC) DLBCL were as...
ORGANISM(S): Homo sapiens 
2010-08-08 | E-GEOD-23501 | biostudies-arrayexpress
TranscriptomicsChronic active pre-B cell receptor signaling drives BCL6 expression and represents a therapeutic target in a distinct subtype of acute lymphoblastic leukemia
BCL6fl/fl mouse bone marrow pre-B cells were transduced with an TCF3-PBX1 vector. The TCF3-PBX1 transduced BCL6fl/fl pre-B cells were then transduced with an empty vector (EV), or a Cre vector for Cre-mediated BCL6 deletion. Effect of BCL6 deletion in the TCF3-PBX1 pre-B cells were studied by Affyme...
ORGANISM(S): Mus musculus 
2015-02-08 | E-GEOD-59332 | biostudies-arrayexpress
GenomicsIntegrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia [ChIP-seq]
Integrative epigenomic analysis identifies biomarkers and therapeutic targets in adult B-acute lymphoblastic leukemia. We performed DNA methylation (HELP array) and gene expression profiling in 215 samples of adult B-lineage acute lymphoblastic leukemia (ALL) and 12 normal preB samples. Adult B-lin...
ORGANISM(S): Homo sapiens 
2012-11-27 | E-GEOD-38403 | biostudies-arrayexpress
GenomicsSelf-enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia
We used ChIPseq in primary pre-B acute lymphomablastic leukemia (ALL) cells to identify target genes of the oncogenes TCF3-PBX1 and BCL6 that are involved in leukemogenesis of TCF3-PBX1 pre-B ALL. ChIP-seq using E2A (TCF3), PBX1, p300 and BCL6 antibodies in ICN12 cells (primary pre-B acute lymphomab...
ORGANISM(S): Homo sapiens 
2015-02-08 | E-GEOD-59538 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human resting and IL2 activated natural killer cells
The aim of the study was to investigate the activation of human NK cells by IL2 through analyzing the global gene expression at different time points (0, 2, 8 and 24 hours) after culture with the cytokine IL2 at 100 IU/ml. NK cells with the CD56+/CD16+ and CD3- phenotype were negatively selected by ...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-8059 | biostudies-arrayexpress
GenomicsGenome-wide DNA Methylation is Predictive of Outcome in Juvenile Myelomonocytic Leukemia
Juvenile myelomonocytic leukemia (JMML) is a myeloproliferative disorder of childhood caused by mutations in the Ras pathway. Outcomes in this disease vary dramatically from spontaneous resolution with little or no treatment to rapid relapse after hematopoietic stem cell transplantation. Given the h...
EGAS00001002700 | EGA
TranscriptomicsDNA methylation profiling in primary Diffuse Large B cell Lymphoma (DLBCL) and normal Germinal Center B Cells
Diffuse Large B-Cell Lymphoma (DLBCL) is the most common aggressive form of non-Hodgkin lymphoma with variable biology and clinical behavior. The current classification does not fully explain the biological and clinical heterogeneity of DLBCLs. In this study we carried out genome-wide DNA methylatio...
ORGANISM(S): Homo sapiens 
2014-01-18 | E-GEOD-54200 | biostudies-arrayexpress
GenomicsMethylation_Controls
Methylation Control samples using 450K Array
EGAD00010001449 | EGA
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