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GenomicsGlobal Reorganization of Chromatin Architecture during Embronic Stem Cell Differentiation
The 3D organization of the genome is important for regulation of diverse nuclear processes ranging from transcription to DNA replication. Knowledge of the higher order chromatin structure is critical for understanding mechanisms of gene regulation by long-range control elements such as enhancers and...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-52457 | biostudies-arrayexpress
MetabolomicsCreation and Characterization of a Genomically Hybrid Strain in the Nitrogen-Fixing Symbiotic Bacterium Sinorhizobium meliloti
Many bacteria, often associated with eukaryotic hosts and of relevance for biotechnological applications, harbor a multipartite genome composed of more than one replicon. Biotechnologically relevant phenotypes are often encoded by genes residing on the secondary replicons. A synthetic biology approa...
2021-03-17 | MTBLS576 | MetaboLights
TranscriptomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (RNA-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59966 | biostudies-arrayexpress
GenomicsReplicative senescence is associated with nuclear reorganization and DNA methylation at specific transcription factor binding sites (MBD-seq)
Primary cells enter replicative senescence after a limited number of cell divisions. This process is associated with reproducible changes in DNA methylation (DNAm) at specific sites in the genome. The mechanism that drives senescence-associated DNAm changes remains unknown and may arise through drif...
ORGANISM(S): Homo sapiens 
2015-03-26 | E-GEOD-59960 | biostudies-arrayexpress
UnknownParallel evolution of transcriptome architecture during genome reorganization.
Not available
S-EPMC3205574 | biostudies-literature
UnknownShelterin components mediate genome reorganization in response to replication stress.
Not available
S-EPMC5448194 | biostudies-literature
TranscriptomicsReorganization of nuclear lamina – genome interactions upon differentiation of embryonic stem cells.
The three-dimensional organization of chromosomes within the nucleus and its dynamics during differentiation are largely unknown. We present a genome-wide analysis of the interactions between chromatin and the nuclear lamina during differentiation of mouse embryonic stem cells (ESCs) into lineage-co...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-17051 | biostudies-arrayexpress
GenomicsMeCP2 binding and genome-lamina reorganization precede long neuronal gene
MeCP2 binding and genome-lamina reorganization precede long neuronal gene
PRJNA1280028 | ENA
GenomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions (ChIP-Seq)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4, and Snf2h. The localizatio...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53583 | biostudies-arrayexpress
GenomicsMultiple Overlapping Mammalian Chromatin Remodeling Systems Collaborate Genome-wide at Dynamic Chromatin Transitions (Dnase-Seq)
ATP-dependent chromatin remodeling is an essential process required for the dynamic organization of chromatin structure. Here we describe the genome-wide location and activity of three remodeler proteins with diverse physiological functions in the mouse genome: Brg1, Chd4, and Snf2h. The localizatio...
ORGANISM(S): Mus musculus 
2013-12-24 | E-GEOD-53584 | biostudies-arrayexpress
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