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TranscriptomicsNucleosome loss leads to global transcriptional upregulation and genomic instability during yeast replicative aging
All eukaryotic cells divide a finite number of times, termed replicative aging, but the reason for this is not clear. Consistent with the decreased total histone protein levels in aged Saccharomyces cerevisiae, which is a cause of aging (1), we find that nucleosome occupancy decreases 50% across the...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-26 | E-GEOD-47023 | biostudies-arrayexpress
TranscriptomicsDo different neurons age differently? Direct genome-wide analysis of aging in single identified cholinergic neurons
The complexity of events associated with age-related memory loss (ARML) cannot be overestimated. The problem is further complicated by the enormous diversity of neurons in the CNS and even synapses of one neuron within a neural circuit. Large-scale single-neuron analysis is not only challenging but ...
ORGANISM(S): Aplysia californica 
2010-05-20 | E-GEOD-18783 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse aging lung from two strains C57BL/6J and DBA/2J
We hypothesize that gene expression in the aging lungs of these two strains of mice are divergent thus contributing to the disparity in the phenotypes.re specifically, (1) Aging DBA/2J mice compared to aging C57BL/6 mice are known to be accelerated in their lung physiology andrphometry; (2) C57BL/6...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-6591 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of human mammary artery media during aging
Our goal was to better understand the genes and pathways implicated during arterial media aging. We therefore compared the gene expression profile of human mammary artery media between Young (<60, 8 patients) and old (>75, 7 patients) patients. The microarray data, generated using the Illumina sentr...
ORGANISM(S): Homo sapiens 
2010-12-07 | E-GEOD-16487 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome sequencing reveals dynamic RNA changes in the aging rat brain
Using RNA-seq, 9 cerebral cortex RNA samples were sequenced from 6 month (n=3, 6 individuals pooled), 12 month (n=3, 6 individuals pooled) and 28 month (n=3, 6 individuals pooled) rats. Allowing brain aging in the cerebral cortex to be assessed. Transcriptional profiling of the ageing cerebral corte...
ORGANISM(S): Rattus norvegicus 
2012-05-09 | E-GEOD-34272 | biostudies-arrayexpress
TranscriptomicsAging and MicroRNA Expression in Human Skeletal Muscle
A common characteristic of aging is the loss of skeletal muscle (sarcopenia) which can lead to falls and fractures. MicroRNAs (miRNA) are novel post-transcriptional modulators of gene expression with a potential role as a regulator of skeletal muscle mass and function. The purpose of this study wa...
ORGANISM(S): Homo sapiens 
2010-10-01 | E-GEOD-23527 | biostudies-arrayexpress
GenomicsNfatc1 Orchestrates Aging in Hair Follicle Stem Cells
Mouse hair follicles undergo synchronized cycles. Cyclical regeneration and hair growth is fueled by hair follicle stem cells (HFSCs). We used ChIP-seq to unfold genome-wide chromatin landscapes of Nfatc1 and dissect the biological relevence of its upstream BMP signaling in HFSC aging. Telogen quies...
ORGANISM(S): Mus musculus 
2013-11-14 | E-GEOD-52328 | biostudies-arrayexpress
UnknownSexually divergent DNA methylation patterns with hippocampal aging.
Not available
S-EPMC5676057 | biostudies-literature
TranscriptomicsMethylation Pattern of Human Mesenchymal Stromal Cells
In this study, we have analyzed DNA methylation changes upon long-term culture and aging of MSC by using the HumanMethylation27 BeadChip assessing 27,578 unique CpG sites. Cells were taken from bone marrow aspirates from iliac crest (BM) of healthy donors or from the caput femoris (HIP) of elderly p...
ORGANISM(S): Homo sapiens 
2010-05-14 | E-GEOD-17448 | biostudies-arrayexpress
GenomicsFunctional dissection of ovarian aging-associated genes NDUFS5 and UBE2L3 through integrated genomic analyses and validation
Functional dissection of ovarian aging-associated genes NDUFS5 and UBE2L3 through integrated genomic analyses and validation
PRJNA1215751 | ENA
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