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MetabolomicsIntegrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent

Leishmania donovani is the responsible agent for visceral leishmaniasis (VL) in the Indian subcontinent (ISC). The disease is lethal without treatment and causes 0.2 to 0.4 million cases each year. Recently, reports of VL in Nepalese hilly districts have increased as well as VL cases cau...

2022-09-15 | MTBLS1606 | MetaboLights
ProteomicsKSN01_Proteome_CellLine: Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
Aberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
ORGANISM(S): Homo Sapiens (human) 
2020-12-15 | PXD010107 | JPOST Repository
TranscriptomicsGenomic and transcriptomic analyses of Lactococcus lactis strains
This SuperSeries is composed of the following subset Series: GSE23987: Transcriptomic profiles of six strains of Lactococcus lactis in ultrafiltration-cheese model GSE23990: Comparative genome hybridization profiles of six strains of Lactococcus lactis Refer to individual Series
ORGANISM(S): Lactococcus lactis 
2012-09-07 | E-GEOD-24015 | biostudies-arrayexpress
TranscriptomicsHuman ES cells reveal recurrent genomic instability at 20q11.21
By analyzing five human embryonic stem (hES) cell lines over long-term culture, we detected a recurrent genomic instability in the human genome. An amplification of 2.5–4.6 Mb at 20q11.21, encompassing about 23 genes in common, appeared in four cell lines of different origins. This amplification, ...
ORGANISM(S): Homo sapiens 
2010-05-16 | E-GEOD-13565 | biostudies-arrayexpress
TranscriptomicsComparative genome hybridization profiles of six strains of Lactococcus lactis
The intra sub-species diversity of six strains of Lactococcus lactis subsp. lactis was investigated at the genomic level and in terms of phenotypic and transcriptomic profiles in UF-cheese model. Six strains were isolated from various sources, but all are exhibiting a dairy phenotype. Our results sh...
ORGANISM(S): Lactococcus lactis 
2012-09-07 | E-GEOD-23990 | biostudies-arrayexpress
TranscriptomicsGenomic (in)stability of the breast tumor microenvironment
The breast tumor microenvironment plays an active role in tumorigenesis. Molecular alterations, including epigenetic modifications to DNA, and changes in RNA and protein expression have been identified in tumor-associated stroma; however, there is considerable debate as to whether the stroma is char...
ORGANISM(S): Homo sapiens 
2012-12-21 | E-GEOD-38071 | biostudies-arrayexpress
TranscriptomicsUpregulation of FOXM1 Induces Genomic Instability in Human Epidermal Keratinocytes
Genome-wide 10k SNP profiling of FOXM1B-transduced N/TERT and primary normal human epidermal keratinocytes (NHEK). The aim of this study was to study the cancer initiation role of UVB and FOXM1B upregulation in NHEK. Upregulation of FOXM1B alone (without UVB) was found to directly induce genomic ins...
ORGANISM(S): Homo sapiens 
2010-07-29 | E-GEOD-16937 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of mouse cell lines MMTV-cdc25a;MMTV-neu murine cell line
CDC25A is a critical target of checkpoint, and its overexpression is observed in various cancers. Here we demonstrate that in vivo levels of Cdc25A expression determine the efficiency of transformation and tumorigenesis. Transgenic expression of CDC25A in murine mammary glands cooperates with tumor...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-4767 | biostudies-arrayexpress
TranscriptomicsProgressive genomic instability in the FVB/KrasLA2 mouse model of lung cancer
Alterations in DNA copy number contribute to the development and progression of cancers and are common in epithelial tumors. We have used array Comparative Genomic Hybridization (aCGH) to visualize DNA copy number alterations across the genomes of lung tumors in the KrasLA2 model of lung cancer. C...
ORGANISM(S): Mus musculus 
2011-11-22 | E-GEOD-29230 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiles of six strains of Lactococcus lactis in ultrafiltration-cheese model
The intra sub-species diversity of six strains of Lactococcus lactis subsp. lactis was investigated at the genomic level and in terms of phenotypic and transcriptomic profiles in UF-cheese model. Six strains were isolated from various sources, but all are exhibiting a dairy phenotype. Our results sh...
ORGANISM(S): Lactococcus lactis 
2012-09-07 | E-GEOD-23987 | biostudies-arrayexpress
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