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TranscriptomicsEvaluation of methods for amplification of picogram amounts of total RNA for whole genome expression profiling
For more than a decade, microarrays have been a powerful and widely used tool to explore the transcriptome of biological systems. However, the amount of biological material from cell sorting or laser capture microdissection is much too small to perform microarray studies. To address this issue, RNA ...
ORGANISM(S): Homo sapiens 
2009-06-02 | E-GEOD-15398 | biostudies-arrayexpress
TranscriptomicsRespective Prognostic Value of Genomic Grade and Histological Proliferation Markers in Early Stage (pN0) Breast Carcinoma
Phenotypic and genomic characterization of Early Stage Breast Carcinoma using Training set (n=109) Validation set (n=105) of SNP6 arrays Affymetrix SNP6.0 arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved breast tumoral samples.
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-48064 | biostudies-arrayexpress
TranscriptomicsExpression Data from Uveal Melanoma primary tumors.
A high percentage of uveal melanoma patients develop metastatic tumors that predominately occur in the liver. To identify genes associated with metastasis in this pathology, we studied 63 molecular profiles derived from gene expression microarrays performed from enuceated primary tumors. Metastasis ...
ORGANISM(S): Homo sapiens 
2010-12-14 | E-GEOD-22138 | biostudies-arrayexpress
TranscriptomicsHuntington disease protein accelerates tumour development and metastasis
Huntington disease is a severe neurological disorder caused by an abnormal polyglutamine expansion in the N-terminal of the huntingtin protein. Here we show that breast tumours appear earlier when mutant huntingtin is expressed in an activated polyomavirus middle T antigen (PyVT) mouse breast cancer...
ORGANISM(S): Mus musculus 
2014-04-14 | E-GEOD-28685 | biostudies-arrayexpress
TranscriptomicsAnalysis of allele specific expression and its chromatin state to identify genes that are escaping X chromosome inactivation
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62966 | biostudies-arrayexpress
TranscriptomicsIdentification of SNPs using genomic DNA and allele specific expression using nascent RNA on snp6 array
Disappearance of the Barr body has long been considered a hallmark of cancer, although whether this corresponds to epigenetic instability and transcriptional reactivation, or to genetic loss, has remained unclear. Here we show that in breast cancer cell lines as well as primary breast tumors, the in...
ORGANISM(S): Homo sapiens 
2015-01-22 | E-GEOD-62965 | biostudies-arrayexpress
TranscriptomicsThe inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2015-01-19 | E-GEOD-62907 | biostudies-arrayexpress
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