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TranscriptomicsmiR-126 Orchestrates an Oncogenic Program in B-Cell Precursor Acute Lymphoblastic Leukemia
MicroRNA (miRNA)-126 is a known regulator of hematopoietic stem cell quiescence. We engineered murine hematopoiesis to express miRNA-126 across all differentiation stages. Thirty percent of mice developed monoclonal B cell leukemia, which was prevented or regressed when a tetracycline-repressible mi...
ORGANISM(S): Homo sapiens 
2016-06-14 | E-GEOD-78078 | biostudies-arrayexpress
TranscriptomicsMouse bone marrow cells transfected with mmu-miR-142-3p mimic oligo.
Tumor progression is accompanied by an altered myelopoiesis that causes the accumulation of cells inhibiting anti-tumor T lymphocytes. We previously reported that immunosuppressive cells can be generated in vitro from bone marrow cells (BM) after four days GM-CSF and IL-6 treatment. Here, we describ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-39803 | biostudies-arrayexpress
TranscriptomicsInterferon gene therapy reprograms the leukemia microenvironment inducing protective immunity to multiple tumor antigens
Single-cell transcriptome profiling using a 3' droplet-based platform (Chromium,10x Genomics) of CD11b+ cells isolated from the spleen of control and tumor-bearing mice, treated or not with IFN gene therapy.
ORGANISM(S): Mus musculus 
2019-05-16 | E-MTAB-6487 | biostudies-arrayexpress
TranscriptomicsRNA-seq of mouse macrophages to investigate how interferon gene therapy reprograms the leukemia microenvironment
Bulk transcriptome profiling of macrophages isolated from the spleen of control and tumor-bearing mice, treated or not with IFN gene therapy.
ORGANISM(S): Mus musculus 
2018-07-26 | E-MTAB-6482 | biostudies-arrayexpress
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