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TranscriptomicsMicroarray analysis of gene expression profiles in PBHA-treated THP-1 cells after LPS stimulation
Using microarray analysis, 219 differentially expressed genes were isolated between the LPS group and LPS/PBHA treatment-group (fold change > or < 1.5). These genes were analyzed by KEGG system to reveal the important issues. The analyses of gene ontology were shown that the genes of the specific cl...
ORGANISM(S): Homo sapiens 
2014-11-17 | E-GEOD-52365 | biostudies-arrayexpress
TranscriptomicsThe effect of HO-1 overexpression on microRNA transcriptome in NCI-H292 lung cancer cells
The aim was to determine the effect of heme oxygenase-1 (HO-1) overexpression on microRNA transcriptome in human non-small cell lung carcinoma cell line (NCI-H292). Since the cells of different HO-1 genotypes were used (cells are after retroviral transduction with empty vector with normal level of H...
ORGANISM(S): Homo sapiens 
2013-04-27 | E-GEOD-37779 | biostudies-arrayexpress
TranscriptomicsQuinacrine Overcomes Resistance to Erlotinib by Inhibiting FACT, Nuclear Factor-kappa B and Cell Cycle Progression in Non-Small Cell Lung Cancer
Erlotinib is a tyrosine kinase inhibitor (TKI) that is approved as a second-line monotherapy in patients with advanced non-small cell lung cancer (NSCLC). In these patients, erlotinib prolongs survival but its benefit remains modest since many tumors express wild-type EGF receptor (wtEGFR) lacking a...
ORGANISM(S): Homo sapiens 
2014-06-19 | E-GEOD-57422 | biostudies-arrayexpress
TranscriptomicsCCRF-CEM Prednisolone and MG132 treatments at 4h
Background: The combination of Proteasome inhibitor with Glucocorticoid is one of the most promising antileukemic treatments. Both agents act through pluripotent signal mediators. The two types of agents inhibit key signals that are considered crucial to their effects on malignant cells. Methodology...
ORGANISM(S): Homo sapiens 
2011-05-11 | E-GEOD-29136 | biostudies-arrayexpress
MetabolomicsAssessing the impact of nitrogen supplementation in oats across multiple growth locations and years with targeted phenotyping and high-resolution metabolite profiling approaches
Oats (Avena sativa L.) are a healthy food, being high in dietary fibre (e.g. β-glucans), antioxidants, minerals, and vitamins. Understanding the effect of variety and crop management on nutritional quality is important. The response of four oat varieties to increased nitrogen levels was investigated...
2021-04-26 | MTBLS1801 | MetaboLights
TranscriptomicsRNAi knock down of VCP in human HeLa cells
Study of the effects of the VCP knockdown. VCP (p97, yeast cdc48) is a hexameric AAA ATPase involved in various cellular functions including degradation of proteins by the ubiquitin-proteasome system. We examine the consequences of the reduction of VCP levels after RNAi of VCP in HeLa cells. We find...
ORGANISM(S): Homo sapiens 
2006-08-23 | E-MEXP-817 | biostudies-arrayexpress
UnknownAdolescent, Parent, and Provider Perceptions of a Predictive Algorithm to Identify Adolescent Suicide Risk in Primary Care.
Not available
S-EPMC11056301 | biostudies-literature
TranscriptomicsEffect of Tgfbr2 disruption on gene expression in the aorta of Fbn1 wild-type and Fbn1C1039G mice
We used microarrays to characterize the global changes in gene expression within the ascending aorta of mice due to conditional disruption of TGF-M-NM-2 signaling in smooth muscle and/or due to heterozygous fibrillin-1 mutation. Myh11-CreERT2.Tgfbr2f/f (abbreviated as Cre.Tgfbr2) mice were cross-bre...
ORGANISM(S): Mus musculus 
2013-05-31 | E-GEOD-36778 | biostudies-arrayexpress
ModelsCondorelli2001_GuanylateCyclase
This model features the observations of Condorelli P, George SC. Biophys J. (2001) 80(5):2110-9. They propose a in vivo mechanism for the binding of free NO to sGC based on in vitro data within both pulmonary and vascular smooth muscle. All the parameters used have been obtained from reported result...
2005-01-01 | MODEL4780441670 | BioModels
TranscriptomicsBET Protein Inhibitor JQ1 Induces Cell Cycle Arrest in Mesenchymal Stem Cells
Efficacy and safety of anticancer drugs are traditionally studied using cancer cell lines and animal models. Recently, a potential anticancer agent, JQ1, an inhibitor of bromodomain and extra terminal (BET) protein, has been shown to promote apoptosis of cancerous cells by arresting them in G1 phase...
ORGANISM(S): Homo sapiens 
2016-02-12 | E-GEOD-70577 | biostudies-arrayexpress
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