Germline development

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Unknown (4303)
Genomics (1451)
Transcriptomics (1177)
Proteomics (64)
Methylation profiling (62)
Other (52)
Genomic (17)
Metabolomics (5)
Clinical (1)

Organisms

Mus musculus (511)
Homo sapiens (439)
Caenorhabditis elegans (254)
Drosophila melanogaster (130)
Arabidopsis thaliana (36)
Danio rerio (33)
Rattus norvegicus (27)
Saccharomyces cerevisiae (19)
Ascaris suum (12)
Burkholderia cenocepacia (9)
Sus scrofa (9)
Gallus gallus (8)
Halobacterium salinarum (7)
Streptococcus pneumoniae (7)
Paramecium tetraurelia (7)
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Salmo salar (6)
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Burkholderia multivorans (4)
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Canis lupus familiaris (4)
Oncorhynchus mykiss (4)
Oxytricha trifallax (4)
Gerbera hybrid cultivar (3)
Schizosaccharomyces pombe (3)
Pseudomonas aeruginosa (3)
Escherichia coli (3)
Oikopleura dioica (3)
Candida albicans WO-1 (2)
Oncorhynchus nerka (2)

Organisms

Mus musculus (326)
Homo sapiens (171)
Caenorhabditis elegans (99)
Drosophila melanogaster (68)
Arabidopsis thaliana (27)
Danio rerio (23)
Rattus norvegicus (18)
Ascaris suum (7)
Parascaris univalens (7)
Zea mays subsp. mays x Zea mays subsp. mexicana (5)
Mesocricetus auratus (5)
Macaca mulatta (5)
Petromyzon marinus (4)
Paramecium tetraurelia (4)
Mus (4)
Saccharomyces cerevisiae (4)
Gallus gallus (4)
Boechera gunnisoniana (3)
Parhyale hawaiensis (3)
Oxytricha trifallax (3)
Xenopus laevis (3)
Patiria miniata (2)
Tetrahymena thermophila (2)
Botryllus schlosseri (2)
Oikopleura dioica (2)
Sus scrofa (2)
Vitis vinifera (2)
Bos taurus (2)
Taeniopygia castanotis (1)
Sterkiella histriomuscorum (1)

Repository

ENA (1026)
biostudies-arrayexpress (843)
geo (759)
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pride (47)
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Tissue

Cell culture (10)
Whole body (6)
Embryonic stem cell (4)
Embryo (3)
Testis (3)
Blood (2)
Oocyte (2)
Ovary (2)
Pancreatic islet (2)
Adult stem cell (1)
B cell (1)
Blood cell (1)
Brain (1)
Breast (1)
Breast cancer cell (1)
Cell suspension culture (1)
Cervical region (1)
Embryonic kidney cell line (1)
Epithelial cell (1)
Floret (1)
Flower (1)
Germ line stem cell (1)
Haematopoietic stem cells (1)
Hematopoietic cell (1)
Kidney (1)
MCF-7 cell (1)
Medulloblastoma cell (1)
Pluripotent stem cell (1)
Pollen (1)
Somatic cell (1)

Disease

Normal (5)
Neuroendocrine tumor (1)
Uterine fibroid (1)
Hutchinson-Gilford Progeria Syndrome (1)
Hereditary pheochromocytoma (1)
Acute myelomonocytic leukaemia (1)
Tumour (1)
Small cell lung carcinoma (1)
Burkitt lymphoma (1)
Melanoma (1)
Acute promyelocytic leukemia (1)
N/a (1)
Central nervous system cancer (1)
Lymphoma (1)
Acute leukemia (1)
Breast cancer (1)
Cervix carcinoma (1)
Lyme disease (1)
Mutational_hotspot (1)
Noonan syndrome (1)

Technology Type

Mass Spectrometry (47)
Shotgun proteomics (25)
Affinity purification coupled with mass spectrometry proteomics (9)
Illumina HiSeq 2000 (7)
Mass spectrometry (5)
Bottom-up proteomics (5)
Data-dependent acquisition (5)
SWATH MS (3)
Illumina HiSeq 2000, ILLUMINA (2)
Affinity proteomics (2)
Illumina HiSeq 2000, ILLUMINA, Illumina HiSeq 4000 (1)
ABI_SOLID, AB 5500xl Genetic Analyzer, AB SOLiD 4 System (1)
Affymetrix OncoScan FFPE Express (1)
Illumina HiSeq 2500, ILLUMINA (1)
454 GS FLX Titanium, Illumina HiSeq 2000 (1)
ILLUMINA, Illumina HiSeq 2000 (1)
Illumina HiSeq 2000, Illumina Genome Analyzer IIx (1)
Illumina HiSeq 2500 (1)
ILLUMINA, Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
Illumina Genome Analyzer II, Illumina HiSeq 2000 (1)
Gel-based experiment (1)
Top-down proteomics (1)

Instrument Platform

Illumina HiSeq 2000 (13)
Illumina HiSeq 2500 (11)
Illumina NovaSeq 6000 (9)
Illumina Genome Analyzer IIx (3)
Illumina HiSeq 4000 (3)
NextSeq 500 (3)
Axon- GenePix4000B (2)
HiSeq X Ten (2)
ShARC (1)
Agilent 2100 (1)
General usage Laborartory equipment (1)
Lab Centrifuge (1)
Agilent G2565BA Microarray Scanner System (Agilent Technologies, Santa Clara, CA) (1)
Tecan HS4800 hybridization station (Tecan, Vienna, Austria) (1)
Illumina HiSeq X-ten (1)
Agilent DNA Microarray Scanner Model #G2565BA (1)
IScan (Illumina) (1)
454 GS FLX (1)
DNA Microarray Scanner C (#G2505C; Agilent Technologies) (1)
Labfors 3 Chemostat (Infors, Switzerland) (1)
Complete Genomics (1)
Illumina HiSeq (1)
ScanArray scanning hardware (1)
G2565AA DNA microarray scanner [Agilent] (1)
G2505A DNA microarray scanner [Agilent] (1)
G2565BA DNA microarray scanner [Agilent] (1)
G2505B DNA microarray scanner (1)
GenePix 4000B [Axon Instruments] (1)
Illumina Genome Analyzer II (1)
Scanning hardware (1)

Publication Date

2010 (224)
2013 (132)
2025 (108)
2015 (101)
2011 (101)
2023 (98)
2012 (97)
2021 (90)
2024 (85)
2014 (77)
2022 (73)
2026 (69)
2020 (57)
2016 (57)
2008 (53)
2017 (52)
2009 (48)
2019 (46)
2018 (40)
2007 (29)
2005 (14)
2006 (12)
2004 (4)
2003 (4)

CHEBI ID

CHEBI:17768 (3)
CHEBI:73688 (3)
CHEBI:17858 (3)
CHEBI:16040 (3)
CHEBI:16708 (3)
CHEBI:6650 (3)
CHEBI:17154 (3)
CHEBI:16259 (3)
CHEBI:7916 (3)
CHEBI:17012 (3)
CHEBI:48131 (3)
CHEBI:16704 (3)
CHEBI:17053 (3)
CHEBI:16015 (3)
CHEBI:16027 (3)
CHEBI:30915 (3)
CHEBI:16919 (3)
CHEBI:17895 (3)
CHEBI:17295 (3)
CHEBI:17596 (3)
CHEBI:17368 (3)
CHEBI:30769 (3)
CHEBI:67040 (2)
CHEBI:24266 (2)
CHEBI:34687 (2)
CHEBI:18283 (2)
CHEBI:71179 (2)
CHEBI:18307 (2)
CHEBI:16552 (2)
CHEBI:48430 (2)

Metabolite Name

Folic acid (2)
Pantothenic acid (2)
N-Acetyl spermine (1)
N-Acetyl putrescine (1)
Cadaverin (1)
N-Acetyl spermidine (1)
Tiglyl-Carnitine (1)
5-methyl tetrahydrofolic acid (1)
Succinyl-coa (1)
5?-Methylthioadenosine (1)
Dimethyl arginine (1)
SAM (1)
Uridine 5'-diphosphoglucuronic acid (1)
SAH (1)
L-Glutathione (reduced) (1)
N-Acetyl-1-aspartylglutamic acid (1)
Riboflavine (1)
Uridine 5'-diphosphogalactose (1)
Cyclic ADP-ribose (1)
L-Glutathione oxidized (1)
Guanosine monophosphate (GMP) (1)
CoA (1)
L-2-Aminoadipate (1)
Tiglyl-CoA (1)
Agmatine (1)
AICA ribonucleotide (1)
2,5-di-tert-Butylhydroquinone (1)
Uridine monophosphate (UMP) (1)
S-Lactoylglutathione (1)
Cystathionine (1)

First Public Date

2025 (133)
2023 (114)
2024 (109)
2021 (91)
2026 (90)
2014 (81)
2022 (79)
2020 (63)
2018 (55)
2017 (51)
2019 (48)
2013 (40)
2015 (38)
2016 (32)
2012 (2)

Classification

helminths (8)

Study status

Recruiting (1)

Study type

Transcription profiling by array (371)
ChIP-seq (108)
RNA-seq of coding RNA (70)
Transcription profiling by tiling array (61)
Unknown experiment type (56)
Comparative genomic hybridization by array (38)
RNA-seq of non coding RNA (37)
Methylation profiling by high throughput sequencing (18)
Methylation profiling by array (16)
ChIP-chip by tiling array (14)
Other (9)
DNA-seq (8)
ChIP-chip by array (5)
Genotyping by array (4)
Animal - High-throughput sequencing (3)
Genotyping by high throughput sequencing (3)
Transcription profiling by RT-PCR (2)
Spatial transcriptomics by high-throughput sequencing (2)
MicroRNA profiling by array (2)
RNA-seq of total RNA (2)
Transcription profiling by SAGE (1)
Cell line - Two-color microarray (1)
MicroRNA profiling by high-throughput sequencing (1)
Human - High-throughput sequencing (1)
Whole chromosome random sequencing (1)
CLIP-seq (1)
Exome sequencing (1)
RIP-seq (1)
CUT&RUN (1)
RNA-seq of coding RNA from single cells (1)

Release Date

2022 (427)
2021 (419)
2023 (390)
2020 (381)
2025 (375)
2024 (328)
2019 (296)
2010 (284)
2018 (282)
2017 (256)
2016 (255)
2015 (246)
2013 (238)
2014 (229)
2011 (181)
2012 (176)
2009 (100)
2008 (90)
2007 (51)
2026 (38)
2006 (35)
2005 (25)
2004 (11)
2003 (9)
2000 (7)
2002 (4)
1999 (4)
2001 (3)
1998 (3)
1997 (3)

Lab affiliation

Shanghai Jiao Tong University (2)
Assistant professor, School of Biological Sciences, Seoul National University. (1)
Associate Professor, University of Washington (1)
CNRS UMR7242, Biotechnology and Cell Signaling, University of Strasbourg, 300 Bd Sébastien Brant, 67412 Illkirch, France (1)
Charité-University Medicine Berlin (1)
Deparment of Molecular Biology and Genetics Aarhus University, Denmark (1)
Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine (1)
Department of Biochemistry and Molecular Biology, School of Life Sciences, Central South University, No. 172, Tongzipo road, Yuelu District, Changsha 410013, Hunan Province, China (1)
Department of Biological Sciences The University of Texas at El Paso US (1)
Department of Biological Sciences, University of Southern California, Los Angeles CA (1)
Department of Gene Expression, Faculty of Biology, Adam Mickiewicz University in Poznan, Poznan, Poland (1)
Department of Molecular Biology and Genetics, Aarhus University, Denmark (1)
Department of Molecular Biology, Faculty of Science, Radboud Institute for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen,6525 GA, The Netherlands (lab head) (1)
Department of Molecular Genetics (190g), University of Hohenheim (1)
Department of Molecular Medicine, The Scripps Research Institute, La Jolla, California 92037 United States (1)
Department of Proteomics and Signal Transduction, Max Planck Institute for Biochemistry, Martinsried, Germany (1)
Director of Proteomics Core (1)
Director of the Proteomics Core at Indiana University School of Medicine (1)
Head of the Curie Institute Mass Spectrometry Platform (1)
Head of the Mass Spectrometry facility of the Institut Curie (LSMP) (1)
Institute for Genome Stability in Ageing and Disease, Medical Faculty, University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany Cologne Excellence Cluster for Cellular Stress Responses in Ageing-Associated Diseases (CECAD), Center for Molecular Medicine Cologne (CMMC), University of Cologne, Joseph-Stelzmann-Str. 26, 50931 Cologne, Germany (1)
Institute of Biodynamics and Biocomplexity (IBB) Department of Biology Faculty of Science Utrecht University Kruytbuilding N806 Padualaan 8, 3584 CH Utrecht The Netherlands (1)
Institute of Molecular Biology (IMB) (1)
Institute of Molecular Biology (IMB), Mainz, Germany (1)
Johns Hopkins University School of Medicine (1)
Key Laboratory for the Genetics of Developmental & Neuropsychiatric Disorders (Ministry of Education), Bio-X Institutes, Shanghai Jiao Tong University, Shanghai, 200240, China. (1)
Laboratory of Non-coding RNA and Genome Rearrangements, Institute of Biochemistry and Biophysics, PAS (1)
Laboratory of Non-coding RNA and Genome Rearrangements, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland (1)
Leibniz Institute on Aging, Fritz Lipmann Institute (FLI) (1)
Marseille Proteomics, Inserm UMR1068, CNRS UMR7258, Aix Marseille Université U105, Institut Paoli Calmettes (1)

Location

United States (1)

Keyword

Genome analysis (1)
Genetic modifiers (1)
Next generation sequencing (NGS) (1)
Heritable disease (1)
Cancer risk (1)
Genetic predisposition (1)
Genetic counseling (1)
DNA (1)

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Novel functions of the ubiquitin-independent proteasome system in regulating Xenopus germline development

In most species, early germline development occurs in the absence of transcription with germline determinants subject to complex translational and post-translational regulations. Here, we report for the first time that early germline development is influenced by dynamic regulation of the proteasome ...

ORGANISM(S): Xenopus laevis (African clawed frog)

2019-04-10 | PXD013446 | Pride

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila

In Drosophila, Piwi proteins associate with Piwi-interacting RNAs (piRNAs) and protect the germline genome by silencing mobile genetic elements. This defense system acts in germline and gonadal somatic tissue to preserve germline development. Genetic control for these silencing pathways varies great...

ORGANISM(S): Drosophila melanogaster

2011-09-28 | E-GEOD-30360 | biostudies-arrayexpress

Silencing of Germline-Expressed Genes by DNA Elimination in Somatic Cells

Chromatin diminution is the programmed elimination of specific DNA sequences during development. It occurs in diverse species, but the function(s) of diminution and the specificity of sequence loss remain largely unknown. Diminution in the nematode Ascaris suum occurs during early embryonic cleavage...

ORGANISM(S): Ascaris suum

2012-11-13 | E-GEOD-38470 | biostudies-arrayexpress

DRM complex mutant lin-54 vs. H3K36 methyltransferase mutant mes-4 vs. lin-54; mes-4 double mutant vs. wild type C.elegans germline

Here we uncover antagonistic regulation of transcript levels in the germline of Caenorhabditis elegans hermaphrodites. The histone methyltransferase MES-4 marks genes expressed in the germline with methylated Lys36 on histone H3 (H3K36me) and promotes their transcription; MES-4 also represses genes ...

ORGANISM(S): Caenorhabditis elegans

2013-11-05 | E-GEOD-52064 | biostudies-arrayexpress

Vreteno, a gonad-specific protein, is essential for germline development and primary piRNA biogenesis in Drosophila.

Here, we analyzed small RNA libraries derived from ovarian tissues heterozygous or mutant for the Tudor gene, Vreteno. In the absence of vret, Piwi-bound piRNAs are lost without changes in piRNA precursor transcript production, supporting a role for Vret in primary piRNA biogenesis. In the germline,...

ORGANISM(S): Drosophila melanogaster

2011-08-15 | E-GEOD-30088 | biostudies-arrayexpress

piRNA during germline development in Drosophila

From embryo to adult: piRNA-mediated silencing throughout germline development in Drosophila

PRJEB18538 | ENA

Early female germline development in Xenopus laevis: Stem cells, nurse cells and germline cysts

PRJNA1303448 | ENA

FGF independent MEK1/2 signalling is essential for male germline development in mice [somatic cell]

PRJNA914333 | ENA

FGF independent MEK1/2 signalling is essential for male germline development in mice [germ cell]

PRJNA914327 | ENA

A Transcription Factor Functional Atlas of Germline Development in Caenorhabditis elegans