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ProteomicsMYCN and MAX alterations in Wilms tumor and identification of novel interactors as biomarker candidates
Wilms tumor (WT) is the most common renal tumor in childhood. Among others, MYCN copy number gain and MYCN P44L and MAX R60Q mutations have been identified in WT. The proto-oncogene MYCN encodes a transcription factor that requires dimerization with MAX to activate transcription of numerous target g...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025996 | Pride
Wilms tumour Prognostic marker N-myc Kidney Pediatric cancer 
TranscriptomicsGene expression data from Wilms tumor samples
Wilms tumor (nephroblastoma) is a pediatric kidney tumor that arises from renal progenitor cells. Since the blastemal type is associated with adverse prognosis, we characterized such Wilms tumors by exome and transcriptome analysis. We detected novel, recurrent somatic mutations affecting the SIX1/2...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-53224 | biostudies-arrayexpress
UnknownGain of 1q As a Prognostic Biomarker in Wilms Tumors (WTs) Treated With Preoperative Chemotherapy in the International Society of Paediatric Oncology (SIOP) WT 2001 Trial: A SIOP Renal Tumours Biology Consortium Study.
Not available
S-EPMC5505170 | biostudies-literature
TranscriptomicsMutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors
Blastemal histology in chemotherapy-treated pediatric Wilms tumors (nephroblastoma) is associated with adverse prognosis. To uncover the underlying tumor biology and find novel therapeutic leads for this subgroup of patients, we analyzed 58 blastemal-type Wilms tumors by exome and transcriptome sequ...
ORGANISM(S): Homo sapiens 
2015-02-18 | E-GEOD-60081 | biostudies-arrayexpress
TranscriptomicsRetinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro
Wilms tumor (WT) is one of the most common malignancies in childhood. With current therapy protocols up to 90 % of patients can be cured, but there is still a need to improve therapy for patients with aggressive WT and to reduce treatment intensity where possible. Prior data suggested deregulation o...
ORGANISM(S): Homo sapiens 
2012-04-20 | E-GEOD-28807 | biostudies-arrayexpress
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