Sort   by:  
 Page size 
TranscriptomicsDifferentially regulated genes in control and c-myc N-myc deficient LT-HSCs
Analysis of HSCs from control and c-myc N-myc deficient long-term hematopoietic stem cells. HSCs lacking both c-myc and N-myc display increased apoptosis rates. Data provide insight into the molecular changes occuring upon complete loss of Myc activity, clarifying the resulting apoptotic mechanism a...
ORGANISM(S): Mus musculus 
2009-02-20 | E-GEOD-12467 | biostudies-arrayexpress
ProteomicsInteraction of N-myc with TFIIIC5 DBD ΔΔ characterised by HDX-MS
Here we characterise the interaction between N-myc with TFIIIC5 DBD ΔΔ by HDX-MS.
ORGANISM(S): Homo sapiens (Human) 
2026-03-09 | PXD054754 | Pride
N-myc Hdx-ms Tfiiic5 dbd 
TranscriptomicsMyc and N-myc induce distinct medulloblastoma subgroups via Miz1
Medulloblastomas (MBs) are cerebellar tumors that can be classified into molecularly distinct subgroups that differ in pathology and prognosis. The mechanisms that underlie subgroup specification are largely unknown. While human SHH MBs express MYCN, Group3 (G3) MBs are associated with c-MYC (MYC) o...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-66093 | biostudies-arrayexpress
ProteomicsThe N-Myc MB0-MBI region interacts specifically and dynamically with the N-lobe of Aurora kinase A
The intrinsically disordered MYC proteins are master regulators of cellular growth and function, but when deregulated become cancer drivers. MYC-protein interactions are key to oncogenesis, and while disrupting such interactions would be of significant therapeutic benefit, the intrinsically disorder...
ORGANISM(S): Homo sapiens (Human) 
2026-01-29 | PXD062561 | Pride
GenomicsDisruption of KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models
Disruption of KLHL37-N-Myc complex restores N-Myc degradation and arrests neuroblastoma growth in mouse models
PRJNA1252111 | ENA
TranscriptomicsThe miR-17/92 Polycistron Is Up-regulated in Sonic Hedgehog-Driven Medulloblastomas and Induced by N-myc in Sonic Hedgehogâ??Treated Cerebellar Neural Precursors
Medulloblastoma is the most common malignant pediatric brain tumor, and mechanisms underlying its development are poorly understood. We identified recurrent amplification of the miR-17/92 polycistron proto-oncogene in 6% of pediatric medulloblastomas by high-resolution single-nucleotide polymorphism...
ORGANISM(S): Homo sapiens 
2010-04-14 | E-GEOD-21166 | biostudies-arrayexpress
TranscriptomicsExpression data from cochlea isolated from N-myc mutant and wild-type mice at E15
The aim of this study consists in detecting genes regulated by N-myc in the murine cochlea In this data set we present 2688 genes differentially regulated by Nmyc in the murine cochlea. These data serve as a platform for verifying their differential regulation by N-myc via RNA in situ hybridisation ...
ORGANISM(S): Mus musculus 
2014-09-16 | E-GEOD-61406 | biostudies-arrayexpress
GenomicsPhase separation of N-myc differentially modulates the transcriptom
Phase separation of N-myc differentially modulates the transcriptom
PRJNA1080601 | ENA
TranscriptomicsDifferential gene expression in neuroblastoma cells after transfection with control siRNA, N-Myc siRNA-1, N-Myc siRNA-2, lncMycN siRNA-1 or lncMycN siRNA-2
N-Myc oncoprotein induces neuroblastoma by modulating gene transcription, and long noncoding RNAs exert biological effects by regulating gene expression. We analysed whether N-Myc and the long noncoding RNA lncMycN mediate the expression of common subsets of genes. Neuroblastoma Kelly cells were tra...
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-50959 | biostudies-arrayexpress
GenomicsMitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
Mitotic gene regulation by the N-MYC-WDR5-PDPK1 nexus
PRJNA1025876 | ENA
Sort   by:  
 Page size