Dataset Information
Interaction of N-myc with TFIIIC5 DBD ΔΔ characterised by HDX-MS
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: 
Antonio Calabrese
LAB HEAD: Antonio Calabrese
PROVIDER: PXD054754 | Pride | 2026-03-09
REPOSITORIES: Pride
Dataset's files
| Action | DRS | |||
|---|---|---|---|---|
| 220208.DnX | Other | |||
| 220208NMyc.DnX | Other | |||
| fbsaca_HDX_240205_03.raw.zip | Raw | |||
| fbsaca_HDX_240205_05.raw.zip | Raw | |||
| fbsaca_HDX_240205_07.raw.zip | Raw |
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Publications
Mechanism of interaction between the transactivation domain of N-myc and the DNA-binding surface of TFIIIC5.
Nucleic acids research 20260201 5
N-myc is a transcription factor, a powerful driver of cellular growth and an important oncoprotein. N-myc interacts with many factors, including the RNA Polymerase III assembly factor, TFIIIC, a six-subunit complex that is essential for the transcription of small, structured RNA. TFIIIC and N-myc mutually restrict each other's chromatin association, and their complex contributes to quality control in mRNA transcription. We previously demonstrated that the intrinsically disordered transactivation ...[more]