Dataset Information
HDX-MS analysis of BAM variants
Ontology highlight
ABSTRACT:
INSTRUMENT(S):
ORGANISM(S): Escherichia Coli
SUBMITTER: 
Antonio Calabrese
LAB HEAD: Antonio Calabrese
PROVIDER: PXD057055 | Pride | 2025-10-13
REPOSITORIES: Pride
Dataset's files
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Publications
Molecular insights into how the motions of the β-barrel and POTRA domains of BamA are coupled for efficient function.
Nature communications 20251003 1
The β-barrel assembly machinery (BAM) inserts β-barrel proteins into the outer membrane of Gram-negative bacteria, forming an essential permeability barrier. The core BAM component, BamA, is a β-barrel protein with an N-terminal periplasmic extension comprising five polypeptide transport-associated (POTRA) domains. Whilst BamA's structure is well characterised, it remains unclear how β-barrel and POTRA domain motions are coordinated. Using BamA variants with mutations in the hinge region between ...[more]