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ProteomicsFam49/CYRI interacts with Rac1 and locally suppresses protrusions
Actin-based protrusions driving cell migration are reinforced through positive feedback, but it is unclear how the cell restricts the eventual size of protrusions, or limits positive signals to allow them to split or retract. We have identified an evolutionarily conserved regulator of the protrusio...
ORGANISM(S): Dictyostelium discoideum (Slime mold) 
2018-10-08 | PXD010460 | Pride
Lamellipodia Cyfip-related rac interactor Dictiostelium discoideus Gfp-trap with formaldehyde crosslinking Scar/wave complex Cell migration 
ProteomicsMitochondrial translocase blocking ATP5MG-tFT fusion protein interactome in human embryonic kidney (HEK) 293 cells
The experiment uses HEK-293 Flp-In T-Rex cells to express fusion protein that combines ATP synthase subunit ATP5MG with a tandem fluorescent protein timer (tFT). The tFT tag combines mCherry and super folder GFP (sfGFP) fluorescent proteins. An exceptionally stable structure of sfGFP interferes with...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD038583 | Pride
Translocase of the outer mitochondrial membrane Protein import Quality control Mitochondria Translocation 
ProteomicsDiscovery of RUF6 ncRNA interacting proteins involved in P. falciparum immune evasion
RUF6 is a ncRNA gene family that is transcribed by RNA Polymerase III but actively regulates the Pol II-transcribed var virulence gene family. Understanding how RUF6 ncRNA connect to downstream effectors is lacking. We developed an RNA-directed proteomic discovery (ChIRP-MS) protocol to identify in ...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2022-11-15 | PXD036801 | Pride
Var genes Malaria virulence Ruf6 ncrna Plasmodium falciparum Antigenic variation 
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