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TranscriptomicsTranscription profiling of mouse 3T3-F442A adipocytes treated with or without growth hormone (GH) to identify a mechanism for regulation of activating transcription factor 3 by GH
Expression profiling of 3T3-F442A adipocytes treated with growth hormone (GH, 500 nM) or vehicle (DMEM + 1% BSA) control for 30 min., 4 hr., or 48 hr in three independent experiments. Chronic GH treatment induces metabolic changes consistent with insulin resistance in 3T3-F442A adipocytes.
ORGANISM(S): Mus musculus 
2007-09-21 | E-GEOD-2120 | biostudies-arrayexpress
GenomicsGenome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.
Signal Transducers and Activators of Transcription (STAT) 5A/B regulate cytokine-inducible genes upon binding to GAS motifs. It is not known what percentage of genes with GAS motifs bind to and are regulated by STAT5. Moreover, it is not clear whether genome-wide STAT5 binding is modulated by its co...
ORGANISM(S): Mus musculus 
2012-01-12 | E-GEOD-34986 | biostudies-arrayexpress
TranscriptomicsContinuous GH treatment of old rat liver
Effect of continuous GH treatment on old rat liver. Male rats, 2-year-old, were treated with vehicle or human GH (0.34 microgram/gram body weight) for 3 weeks. Comparison of treated and untreated rats. Individual RNA were used for 4 microarray hybridization. Dye swapped.
ORGANISM(S): Rattus norvegicus 
2010-06-09 | E-GEOD-2962 | biostudies-arrayexpress
TranscriptomicsExpression data from human (h-) growth hormone-treated and untreated chimeric mouse liver repopulated with human hepatocytes
We generated h-hepatocyte chimeric mice with livers that were predominantly repopulated with h-hepatocytes in a h-growth hormone (GH)-deficient state. Using microarray profiles, comparison between h-hepatocytes from h-GH-treated and untreated mice identified 14 GH-up-regulated and four GH-down-regul...
ORGANISM(S): Mus musculus 
2011-01-25 | E-GEOD-26224 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human adipose tissue from hypopituitary men before and after growth hormon (GH) treatment.
Adipose tissue is a major target of GH action. GH stimulates lipolysis and reduces fat mass. The molecular mechanism underlying cellular and metabolic effects of GH in adipose tissue is not well understood. The aim of this study is to identify GH-responsive genes that regulate lipid metabolism in ad...
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MTAB-276 | biostudies-arrayexpress
TranscriptomicsEffects of domestication and GH transgenesis on mRNA profiles in rainbow trout
Growth rate can be genetically modified in many vertebrates by domestication and selection, and more recently by transgenesis overexpressing growth factor genes (e.g. growth hormone, GH). While the phenotypic end consequence is similar, it is currently not clear whether the same modifications to phy...
ORGANISM(S): Oncorhynchus mykiss 
2013-12-03 | E-GEOD-47562 | biostudies-arrayexpress
GenomicsUnbiased, Genome-wide in vivo Mapping of Transcriptional Regulatory Elements Reveals Sex Differences in Chromatin Structure Associated with Sex-specific Liver Gene Expression
We have used a simple and efficient method to identify condition-specific transcriptional regulatory sites in vivo to help elucidate the molecular basis of sex-differences in transcription, which are widespread in mammalian tissues and affect normal physiology, drug response, inflammation and diseas...
ORGANISM(S): Mus musculus 
2010-09-28 | E-GEOD-21777 | biostudies-arrayexpress
TranscriptomicsDomestication and growth hormone transgenesis cause similar changes in gene expression profiles in coho salmon
By directly comparing gene expression in wild type, domestic, and GH transgenic strains of salmon, we have found that domestication and GH transgenesis are modifying similar genetic pathways. Genes in many different physiological pathways show modified expression in domestic and GH transgenic strain...
ORGANISM(S): Oncorhynchus kisutch 
2009-03-08 | E-GEOD-13846 | biostudies-arrayexpress
GenomicsCellvibrio sp. KY-GH-1 isolate:Sincheon River in Daegu City
Cellvibrio sp. KY-GH-1 isolate:Sincheon River in Daegu City Genome sequencing
PRJNA486222 | ENA
GenomicsMannheimia haemolytica strain:16041065 GH
Mannheimia haemolytica strain:16041065 GH Genome sequencing and assembly
PRJNA349067 | ENA
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