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TranscriptomicsThe rectal cancer microRNAome - a comprehensive comparative analysis of microRNA expression in rectal cancer and matched normal mucosa
Purpose: MicroRNAs play a prominent role in a variety of physiological and pathological biological processes, including cancer. For rectal cancers, only limited data are available on microRNA expression profiles, while the underlying genomic and transcriptomic aberrations have been firmly establishe...
ORGANISM(S): Homo sapiens 
2012-10-05 | E-GEOD-38389 | biostudies-arrayexpress
TranscriptomicsA Gene Expression Signature for Chemoradiosensitivity of Colorectal Cancer Cells
In this study, we use cancer cell lines to investigate the molecular differences between resistant and responsive colorectal cancer cells. Since the treatment of patients with locally advanced rectal cancers involves chemoradiotherapy (CT/RT), we specifically implemented an in vitro protocol that m...
ORGANISM(S): Homo sapiens 
2011-02-10 | E-GEOD-20298 | biostudies-arrayexpress
TranscriptomicsIdentification of a microRNA expression signature for radiochemosensitivity of colorectal cancer cells, involving miRNAs-320a, -224, -132 and let7g
Purpose: Preoperative 5-fluorouracil (5-FU) based radiochemotherapy (RCT) represents the standard treatment for locally advanced rectal cancer. Both, tumor response and progression vary considerably. MicroRNAs represent master regulators of gene expression, and may therefore contribute to this heter...
ORGANISM(S): Homo sapiens 
2013-09-01 | E-GEOD-40976 | biostudies-arrayexpress
UnknownThe rectal cancer microRNAome--microRNA expression in rectal cancer and matched normal mucosa.
Not available
S-EPMC6298229 | biostudies-literature
TranscriptomicsA 50-Gene Predictor of Recurrence as a Guide to Therapy in Early-Stage Colon Cancer.
Gene expression profiles reflect unique aspects of individual biologic phenotypes and may characterize the heterogeneity of solid tumors. Using previously-described methodologies that employ DNA microarray data, a 50-gene expression profile (metagene) that predicts risk of recurrence in early stage ...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-10402 | biostudies-arrayexpress
UnknownSTAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo.
Not available
S-EPMC7706351 | biostudies-literature
TranscriptomicsIdentification and validation of NOL5A and RPS2 as potential therapeutic targtes in colorectal cancer
Identification and validation of NOL5A and RPS2 as potential therapeutic targets in colorectal cancer using a functional genomics approach. To identify potential therapeutic targets for colorectal cancer, we first assessed the functional and molecular consequences of RNAi mediated silencing of candi...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-15212 | biostudies-arrayexpress
UnknownGlobal, regional, and national burden of headache disorders, 1990-2021, with forecasts to 2050: A Global Burden of Disease study 2021.
Not available
S-EPMC12629824 | biostudies-literature
UnknownChanging life expectancy in European countries 1990-2021: a subanalysis of causes and risk factors from the Global Burden of Disease Study 2021.
Not available
S-EPMC11876102 | biostudies-literature
UnknownPancreatic surgery outcomes: multicentre prospective snapshot study in 67 countries.
Not available
S-EPMC10771125 | biostudies-literature
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