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TranscriptomicsThe global transcriptional profile of Mycobacterium tuberculosis during human macrophages infection
During lung infection Mycobacterium tuberculosis (Mtb) resides in macrophages and subverts the bactericidal mechanisms of these professional phagocytes. In this work we have analyzed by DNA microarray technique the global transcription profile of Mtb infecting primary human macrophages in order to i...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-27 | E-GEOD-6209 | biostudies-arrayexpress
TranscriptomicsEffects of CBD on the glioma stem cell molecular signature
Primary glioma stem cells cultured as neurospheres in NBL media with growth factors were subjected to treatment with the non-toxic, non-psychoactive cannabis compound cannabidiol (CBD). Control and CBD- treated cultures were used to generate RNA used to hybridize on Affymetrix DNA arrays Fluorescenc...
ORGANISM(S): Homo sapiens 
2015-04-17 | E-GEOD-57978 | biostudies-arrayexpress
TranscriptomicsIntracellular expression pattern of recombinant Mtb strain TB294 overexpressing sigma factor A
We previously showed that increased expression of the principal sigma factor, SigA, mediates the capacity of Mycobacterium tuberculosis 210 strains to grow more rapidly in human monocytes, compared to other strains. To identify SigA-regulated genes that favor intracellular mycobacterial growth, we u...
ORGANISM(S): Mycobacterium tuberculosis 
2010-10-08 | E-GEOD-13780 | biostudies-arrayexpress
TranscriptomicsCholesterol's effect on M. tuberculosis
2 experiments: (1) Mtb, Tween vs Cholesterol at 3 & 24hrs (2) CDC1551 vs kstR mutant of CDC1551, with and w/o Cholesterol In triplicate, dye flips included.
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-20 | E-GEOD-13978 | biostudies-arrayexpress
TranscriptomicsSigma factor E of Mycobacterium tuberculosis controls the expression of bacterial components that modulate macrophages
Sigma factor E (SigE) controls the expression of genes that are essential for Mtb virulence. In this work, we have identified the SigE regulon during infection of macrophages Our results indicate that SigE regulates the expression of genes involved in the maintenance of Mtb cell envelope integrity a...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-25 | E-GEOD-7962 | biostudies-arrayexpress
TranscriptomicsDevelopmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes
Rationale: The Id1 and Id3 genes play major roles during cardiac development, despite their expression being confined to non-myocardial layers (endocardium â?? endothelium - epicardium). We previously described that Id1â??/â??Id3â??/â?? double knockout (dKO) mouse embryos die at mid-gestation from m...
ORGANISM(S): Mus musculus 
2010-10-07 | E-GEOD-21924 | biostudies-arrayexpress
TranscriptomicsThe sigma factor E of Mycobacterium tuberculosis modulates the inflammatory response of human THP1 cells
Mycobacterium tuberculosis (Mtb) is well adapted to survive in macrophages and usually subverts the bactericidal mechanisms of these professional phagocytes. The adaptation of Mtb to the intracellular life depends on its ability to regulate the expression of its genes. Among the most important bact...
ORGANISM(S): Homo sapiens 
2010-05-25 | E-GEOD-7870 | biostudies-arrayexpress
TranscriptomicsThe sigma factor E of Mycobacterium tuberculosis modulates the inflammatory response of macrophages
Mycobacterium tuberculosis (Mtb) is well adapted to survive in macrophages and usually subverts the bactericidal mechanisms of these professional phagocytes. The adaptation of Mtb to the intracellular life depends on its ability to regulate the expression of its genes. Among the most important bact...
ORGANISM(S): Mus musculus 
2010-05-25 | E-GEOD-7871 | biostudies-arrayexpress
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