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GenomicsGenome-wide mapping of human DNA-replication origins: levels of transcription at Orc1 sites regulate origin selection and replication timing
We report the genome-wide mapping of Orc1 binding-sites in mammals and their validation as active DNA-replication origins (ORIs). Orc1 sites are universally associated with transcription start sites (TSSs) of coding or non-coding RNAs. Transcription levels at the Orc1 sites directly correlate with r...
ORGANISM(S): Homo sapiens 
2012-09-18 | E-GEOD-37583 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of HeLa cells infected with Salmonella Typhimurium
We evaluated the transcriptome changes induced by infection with Salmonella (20 hpi, MOI 100). Transcriptmic profiles of HeLa cells infected with Salmonella Typhimurium were generated by deep sequencing, using Illumina HiSeq 2000.
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53280 | biostudies-arrayexpress
TranscriptomicsTranscript expression levels of neonatal mouse cardiomyocytes mock-transfected, or transfected with cel-miR-67, hsa-miR-590-3p or hsa-miR-199a-3p
To identify the relevant targets of the selected miRNAs, we assessed global transcriptome changes by deep-sequencing total neonatal mouse cardiomyocyte RNA after transfection with hsa-miR-590-3p or hsa-miR-199a-3p Four condition experiment; one replicate per condition; mouse neonatal cardiomyocytes ...
ORGANISM(S): Mus musculus 
2012-10-13 | E-GEOD-41538 | biostudies-arrayexpress
TranscriptomicsProfiling of miRNA expression of HeLa cells infected with Salmonella Typhimurium
We identified miRNAs differentially regulated upon Salmonella infection by comparative deep-sequencing analysis of cDNA libraries prepared from the small RNA population (10M-bM-^@M-^S29 nt) of HeLa cells infected with Salmonella (20 hpi) and mock-treated cells. Considering that at a MOI of 25 Salmon...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53278 | biostudies-arrayexpress
TranscriptomicsRole of microRNAs in the interaction between Salmonella and the host cell
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53281 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of HeLa cells treated with miR-15a, miR-16, miR-503 and control-miR
To have a global picture of the targets of the miR-15 family, we assessed transcriptome changes, by deep-sequencing, of HeLa cells transfected with 3 members of the miR-15 family (miR-15a, miR-16 or miR-503) or a control miRNA (cel-miR-231). We observed a very extensive overlap between the genes dow...
ORGANISM(S): Homo sapiens 
2014-07-18 | E-GEOD-53279 | biostudies-arrayexpress
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