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TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (RNA-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-73859 | biostudies-arrayexpress
TranscriptomicsTranscription factor trapping by RNA in gene regulatory elements (CLIP-Seq)
Transcription factors (TFs) bind specific sequences in promoter-proximal and distal DNA elements in order to regulate gene transcription. RNA is transcribed from both promoter-proximal and distal DNA elements, and some DNA-binding TFs have also been shown to bind RNA. These obsevations led us to p...
ORGANISM(S): Mus musculus 
2015-10-29 | E-GEOD-68196 | biostudies-arrayexpress
Transcriptomicsm6A RNA modification controls cell fate transition in mammalian embryonic stem cells
N6-methyl-adenosine (m6A) is the most abundant modification on messenger RNAs and is linked to human diseases, but its functions in mammalian development are poorly understood. Here we reveal the evolutionary conservation and function of m6A by mapping the m6A methylome in mouse and human embryonic ...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-52600 | biostudies-arrayexpress
Transcriptomicsm6A level and isoform characterization sequencing (m6A-LAIC-seq) reveal the census and complexity of the m6A epitranscriptome
N6-methyladenosine (m6A) is a widespread reversible chemical modification of RNAs, implicated in many aspects of RNA metabolism. Little quantitative information exists as to either how many transcript copies of particular genes are m6A modified (“m6A levels”), or the relationship of m6A modifica...
ORGANISM(S): Homo sapiens 
2016-06-24 | E-GEOD-66086 | biostudies-arrayexpress
TranscriptomicsDivergent transcription of lncRNA/mRNA gene pairs in embryonic stem cells
Many long non-coding RNA (lncRNA) species have been identified in mammalian cells, but the genomic origin, regulation and function of these molecules in individual cell types is poorly understood. We have generated comprehensive catalogs of lncRNA species expressed in human and murine embryonic ste...
ORGANISM(S): Homo sapiens 
2013-01-02 | E-GEOD-41009 | biostudies-arrayexpress
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