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MetabolomicsChemerin sustains the growth of spongiotrophoblast and sinusoidal trophoblast giant cells through fatty acid oxidation

Background: Placental metabolic abnormalities are linked to pregnancy complications such as preeclampsia, gestational diabetes mellitus and fetal growth restriction. However, little is known about how the metabolic processes regulate placental development and trophoblast differentiation. The adip...

2025-06-13 | MTBLS12552 | MetaboLights
TranscriptomicsTranscriptional analysis of giant cells induced by root knot nematodes in rice
Biotrophic plant pathogens have evolved sophisticated strategies to manipulate their host. They derive all of their nutrients from living plant tissues, by making intimate contact with their host while avoiding a resistance response. Rice is one of the most important crop plants worldwide and an exc...
ORGANISM(S): Oryza sativa Japonica Group 
2013-08-07 | E-GEOD-43577 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue
Gene expression profiling of SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue.
ORGANISM(S): Homo sapiens 
2010-08-09 | E-MEXP-2351 | biostudies-arrayexpress
TranscriptomicsEffect of Leptin on Mouse Trophoblast Giant Cells
Leptin, a hormone produced primarily by adipose tissue, plays a role in both energy homeostasis and reproduction, and is required in early pregnancy. Leptin stimulates metalloproteinase activity in cultured human trophoblast and stimulates invasiveness of cultured mouse trophoblast. The goal of th...
ORGANISM(S): Mus musculus 
2010-10-08 | E-GEOD-10297 | biostudies-arrayexpress
TranscriptomicsTenosynovial giant-cell tumor and pigmented villonodular synovitis
Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confir...
ORGANISM(S): Homo sapiens 
2006-02-24 | E-GEOD-4166 | biostudies-arrayexpress
MetabolomicsHypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239
Background: Elevated choline kinase alpha (ChoK) levels are observed in most solid tumors, including glioblastomas (GBM), and ChoK inhibitors have demonstrated limited efficacy in GBM models. Given that hypoxia is associated with resistance to GBM therapy, we hypothesized that tumor hypoxia c...
2024-06-18 | MTBLS6212 | MetaboLights
ProteomicsProtein profile of exosome derived from giant panda adipose-derived mesenchymal stem cells
Exosomes were extracted from adipose mesenchymal stem cells of Qnling giant pandas using ultracentrifugation. Proteomic techniques were applied to analyze the composition and function of ADMSC-EX.
ORGANISM(S): Ailuropoda melanoleuca (Giant panda) 
2025-05-26 | PXD059496 | Pride
Qinling giant pandas acmscs-ex 
TranscriptomicsTrophoblast giant cell underrepresentation (sequencing)
We characterized the mouse trophoblast giant cell epigenome and gene expression profiles. We then compared these data to our data on underrepresentation in the polyploid trophoblast giant cells. We profiled 5 histone modifications (+ chromatin input) using ChIP-Seq, and digital expression profiles ...
ORGANISM(S): Mus musculus 
2014-05-29 | E-GEOD-50561 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human enosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) samples
Tenosynovial giant-cell tumor (TGCT) and pigmented villonodular synovitis (PVNS) are related conditions with features of both reactive inflammatory disorders and clonal neoplastic proliferations. Chromosomal translocations involving chromosome 1p13 have been reported in both TGCT and PVNS. We confir...
ORGANISM(S): Homo sapiens 
2006-06-09 | E-SMDB-3598 | biostudies-arrayexpress
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
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