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TranscriptomicsSelective Functions of Individual Zinc Fingers Within the DNA-Binding Domain of Ikaros (RNA-seq: sorted proB cell Hardy Fractions B and C+C')
The C2H2 zinc finger is the most prevalent DNA-binding motif in the mammalian proteome, with DNA-binding domains usually containing more tandem fingers than are needed for stable sequence-specific DNA recognition. To examine the reason for the frequent presence of multiple zinc fingers, we generated...
ORGANISM(S): Mus musculus 
2013-09-08 | E-GEOD-38842 | biostudies-arrayexpress
GenomicsFunctions of BET proteins in GATA1-mediated transcription [ChIP-seq]
Transcription factor GATA1 binding in erythroblasts in the presence and absence of BET inhibitor JQ1, and BET protein BRD3 and BRD4 binding in erythroblasts in the presence and absence of GATA1. Inhibitors of Bromodomain and Extra-Terminal motif proteins (BETs) are being evaluated for the treatment...
ORGANISM(S): Mus musculus 
2015-02-23 | E-GEOD-62736 | biostudies-arrayexpress
GenomicsPolycomb Group proteins are retained at specific sites on chromatin in mitosis
Epigenetic regulation of gene expression, including by Polycomb Group (PcG) proteins, may depend on heritable chromatin states but how these states can be propagated through mitosis is unclear. Using immunofluorescence and biochemical fractionation, we find PcG proteins associated with mitotic chrom...
ORGANISM(S): Drosophila melanogaster 
2013-01-04 | E-GEOD-38166 | biostudies-arrayexpress
UnknownChromatin structure dynamics during the mitosis-to-G1 phase transition.
Not available
S-EPMC6895436 | biostudies-literature
UnknownComparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element.
Not available
S-EPMC5647940 | biostudies-literature
TranscriptomicsSelective Functions of Individual Zinc Fingers Within the DNA-Binding Domain of Ikaros (RNA-seq: BCR-ABL transformed in vitro cell culture cells)
The C2H2 zinc finger is the most prevalent DNA-binding motif in the mammalian proteome, with DNA-binding domains usually containing more tandem fingers than are needed for stable sequence-specific DNA recognition. To examine the reason for the frequent presence of multiple zinc fingers, we generated...
ORGANISM(S): Mus musculus 
2013-09-08 | E-GEOD-38841 | biostudies-arrayexpress
UnknownGALA, a database for genomic sequence alignments and annotations.
Not available
S-EPMC430176 | biostudies-literature
UnknownS3norm: simultaneous normalization of sequencing depth and signal-to-noise ratio in epigenomic data.
Not available
S-EPMC7192629 | biostudies-literature
UnknownTranscriptional Burst Initiation and Polymerase Pause Release Are Key Control Points of Transcriptional Regulation.
Not available
S-EPMC6368450 | biostudies-literature
TranscriptomicsRNA-seq of estrogen (E2) induced changes of mRNA expression in early pregnant Sus scrofa endometrium
Maternal exposure to estrogens can induce long-term adverse effects in the offspring. This may be mediated through alterations in the endometrium affecting embryo-maternal communication as early as the preimplantational phase. Thus, we analyzed the effects of gestational estradiol-17β (E2) exposure ...
ORGANISM(S): Sus scrofa 
2018-10-16 | E-MTAB-6242 | biostudies-arrayexpress
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