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TranscriptomicsGene expression profiles of M. tuberculosis constitutively expressing the transcriptional regulator DosR (Rv3133c).
Background: Conflicting results have been reported about the role of the two-component sensor and transcriptional regulator DosS/DosR, controlling the expression of the dormancy DosR regulon, for in vivo virulence of M. tuberculosis. Here, we have used a new approach to further analyze the relevance...
ORGANISM(S): Mycobacterium tuberculosis 
2012-06-12 | E-GEOD-19838 | biostudies-arrayexpress
TranscriptomicsCharacterization of mycobacterial oligopeptide permease system
M. tuberculosis strain 1254 wild type (WT) and its isogenic delta Rv3662c-Rv3665c KO (opp KO) and complemented opp::opp were cultured in vitro, in liquid 7H9 media supplemented with OADC and 0.05% Tween 80, 0.5% glycerol, in a 150 mL volume, contained in roller bottles, incubated at 37oC. Growth wa...
ORGANISM(S): Mycobacterium tuberculosis 
2009-10-06 | E-GEOD-18426 | biostudies-arrayexpress
UnknownSARS-CoV-2 Infection: A Role for S1P/S1P Receptor Signaling in the Nervous System?
Not available
S-EPMC7556035 | biostudies-literature
TranscriptomicsRNA-seq of SOX2 positive pituitary cells with and without activation of beta-catenin
RNA-sequencing of FACS sorted YFP +ve (I.e. SOX2 positive) cells from Sox2CreERT/+;R26YFP/+ (n=3) mice (control), and Sox2CreERT/+;CTNNB1lox(ex3)/+;R26YFP/+ (n=3) mice (with activation of beta-catenin).
ORGANISM(S): Mus musculus 
2018-02-01 | E-MTAB-5538 | biostudies-arrayexpress
TranscriptomicsCardiac gene expression analysis in porcine model of heart failure
A gene expression topology of the developing, postnatal and diseased heart resulted in re-interpretation of ventricular remodeling in terms of rearrangement of key gene regulatory networks that are imbalanced, attenuated, or abnormally activated in the failing myocardium. The underlying principle, “...
ORGANISM(S): Sus scrofa 
2012-05-31 | E-GEOD-30110 | biostudies-arrayexpress
MetabolomicsA homeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism

Cellular senescence affects many physiological and pathological processes and is characterized by durable cell cycle arrest, an inflammatory secretory phenotype and metabolic reprogramming. Here, by using dynamic transcriptome and metabolome profiling in human fibroblasts with different subtypes ...

2024-01-09 | MTBLS7118 | MetaboLights
UnknownComparison of bioresorbable vs durable polymer drug-eluting stents in unprotected left main (from the RAIN-CARDIOGROUP VII Study).
Not available
S-EPMC7227223 | biostudies-literature
TranscriptomicsLaser Capture Microdissection and RNA Sequencing Human Adamantinomatous Craniopharyngioma
Laser capture microdissection of cluster cells, palisading epithelium and glial tissue from 2 cases of human adamantinomatous craniopharyngioma. 1 case performed in duplicate.
ORGANISM(S): Homo sapiens 
2018-04-11 | E-MTAB-5266 | biostudies-arrayexpress
TranscriptomicsIn vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine
Background: Genome-wide methylation of cytosine can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes. TET enzymes are able to oxidise 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TDG can excise the oxidat...
ORGANISM(S): Mus musculus 
2016-05-31 | E-GEOD-77447 | biostudies-arrayexpress
UnknownAnalytical performance of commercial myositis-specific autoantibody tests evaluated against immunoprecipitation assays as a reference standard: A systematic review and meta-analysis.
Not available
S-EPMC12858645 | biostudies-literature
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