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TranscriptomicsRedefining the Relevance of Established Cancer Cell Lines to the Study of Clinical Anti-Cancer Drug Resistance
Although in vitro models have been a cornerstone of anti-cancer drug development, their direct applicability to clinical cancer research has actually been uncertain. Using a state-of-the-art Taqman-based qRT-PCR assay, we investigated the multidrug resistance (MDR) transcriptome of six cancer types,...
ORGANISM(S): Homo sapiens 
2011-11-16 | E-GEOD-30034 | biostudies-arrayexpress
TranscriptomicsClinical Relevance of Multidrug Resistance Gene Expression in Ovarian Serous Carcinoma Effusions
The presence of tumor cells in effusions within serosal cavities is a clinical manifestation of advanced-stage cancer and is generally associated with poor survival. Identifying molecular targets may help to design efficient treatments to eradicate these aggressive cancer cells and improve patient s...
ORGANISM(S): Homo sapiens 
2011-11-17 | E-GEOD-29702 | biostudies-arrayexpress
TranscriptomicsIndividual multidrug resistance patterns in AML patients point to the need for personalized molecular analysis
In this unique study, based on paired samples obtained at AML diagnosis and at relapse, we assessed 380 multidrug-resistance-related genes, using TaqMan-based qRT-PCR, as indicated by reports published over the past three decades. 11 paired AML samples taken at diagnosis and at relapse after treatme...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-33787 | biostudies-arrayexpress
TranscriptomicsEvaluation of a Low Density DNA Microarray for Small B-Cell non-Hodgkin’s Lymphoma Differential Diagnosis
Lymphomas are classified according to the World Health Organization (WHO) classification which defines subtypes on the basis of clinical, morphological, immunophenotypic, molecular and cytogenetic criteria. Using this model, 8 of 9 of the validation samples were classified successfully. This pilot s...
ORGANISM(S): Homo sapiens 
2009-03-24 | E-GEOD-11635 | biostudies-arrayexpress
TranscriptomicsMultidrug Resistance-Linked Gene Signature Predicts Overall Survival of Patients with Primary Ovarian Serous Carcinoma
This study assesses the ability of multidrug resistance (MDR)-associated gene expression patterns to predict survival in patients with newly diagnosed carcinoma of the ovary. The scope of this research differs substantially from that of previous reports, as a very large set of genes was evaluated wh...
ORGANISM(S): Homo sapiens 
2012-04-19 | E-GEOD-30009 | biostudies-arrayexpress
TranscriptomicsA role for Multidrug Resistance Protein 4 (MRP4; ABCC4) in human Dendritic Cell migration.
The capacity of dendritic cells (DC) to migrate from peripheral organs to lymph nodes (LN) is an important event in the initiation of a T cell-mediated immune response. Previously it was shown that the ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp; ABCB1) and the 2 multidrug resistanc...
ORGANISM(S): Homo sapiens 
2008-07-12 | E-GEOD-12089 | biostudies-arrayexpress
TranscriptomicsComparison between HuT78 parental and romidpepsin-selected cell lines
Gene expression values were determined for HuT78 parental cells and cells selected with romidpesin in the presence of P-glycoprotein inhibitors. HuT78 DpVp35 cells are maintained in 35 ng/ml romidepsin with 2.5 µg/ml verapamil and HuT78 DpP100 cells are maintained in 100 ng/ml romidepsin with 1 µM v...
ORGANISM(S): Homo sapiens 
2013-03-12 | E-GEOD-45018 | biostudies-arrayexpress
TranscriptomicsProlonged Drug Selection of Breast Cancer Cells and Enrichment of Cancer Stem Cell Characteristics.
Background: Cancer stem cells are presumed to have virtually unlimited proliferative and self-renewal abilities and to be highly resistant to chemotherapy, a feature that is associated with overexpression of ATP-binding cassette transporters. We investigated whether prolonged continuous selection of...
ORGANISM(S): Homo sapiens 
2011-09-25 | E-GEOD-24460 | biostudies-arrayexpress
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