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MetabolomicsUntargeted metabolomics analysis of gingival tissue in patients with severe periodontitis
Periodontitis, as a chronic inflammatory condition, its initiating factor is the plaque biofilm. The inflammation starts in the gingival tissue, if left untreated, may progress to severe periodontitis and cause bone and tooth loss. The purpose of this study was to determine the potential metabolic b...
2026-09-08 | MTBLS8357 | MetaboLights
MetabolomicsLipidomic analysis reveals altered lipid profiles of clinically healthy and periodontitis-affected gingival biopsies

AIM: The role of lipids in periodontitis has not been well studied. Thus, this study aimed to explore periodontitis-associated lipid profile changes and identify differentially expressed lipid metabolites in gingival tissues.

MATERIALS AND METHODS: Gingival...

2022-08-19 | MTBLS4684 | MetaboLights
TranscriptomicsTranscription profiling of gingival tissue from patients with periodontitis: Bacterial Correlates of Gingival Gene Expression
We investigated the association between subgingival bacterial profiles and gene expression patterns in gingival tissues of patients with periodontitis. A total of 120 patients undergoing periodontal surgery contributed with a minimum of two interproximal gingival papillae (range 2-4) from a maxillar...
ORGANISM(S): Homo sapiens 
2009-12-21 | E-GEOD-16134 | biostudies-arrayexpress
TranscriptomicsAssessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures (mRNA data)
Swedish snus is a smokeless tobacco product that contains reduced levels of harmful compounds compared with cigarette smoke. In Sweden, where snus use exceeds smoking among men, relatively low rates of major smoking-related diseases have been recorded. To better understand how snus use could align w...
ORGANISM(S): Homo sapiens 
2019-01-30 | E-MTAB-7579 | biostudies-arrayexpress
TranscriptomicsAssessment of a 72-hour repeated exposure to Swedish snus extract and total particulate matter from 3R4F cigarettes on gingival organotypic cultures (miRNA data)
Swedish snus is a smokeless tobacco product that contains reduced levels of harmful compounds compared with cigarette smoke. In Sweden, where snus use exceeds smoking among men, relatively low rates of major smoking-related diseases have been recorded. To better understand how snus use could align w...
ORGANISM(S): Homo sapiens 
2019-01-30 | E-MTAB-7580 | biostudies-arrayexpress
TranscriptomicsMicroRNAs and their target genes in gingival tissues.
To gain insights into the in vivo function of miRNAs in the context of periodontitis, we examined the occurrence of miRNAs in healthy and diseased gingival tissues and validated their in silico-predicted targets through mRNA profiling using whole-genome microarrays in the same specimens. Eighty-six ...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54710 | biostudies-arrayexpress
TranscriptomicsTranscriptomes in Healthy and Diseased Gingival Tissues
We examined gene expression signatures in healthy and diseased gingival tissues in 90 patients. Analysis of the gingival tissue transcriptome in states of periodontal health and disease may reveal novel insights of the pathobiology of periodontitis. Keywords: gingival tissue disease state analysis N...
ORGANISM(S): Homo sapiens 
2008-12-22 | E-GEOD-10334 | biostudies-arrayexpress
ProteomicsPCT-assisted mass spectrometric quantification of gingival tissue reveals dynamics of protein synthesis during initiation and progression of inflammatory disease
Understanding the progression of periodontal destruction is at the forefront of periodontal research. Therefore, we aimed to capture the dynamics of gingival tissue proteome during initiation and progression of an experimental periodontitis developed by placing silk ligatures on the second molars of...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD014608 | Pride
Experimental periodontitis Gingival tissue Pressure cycling technology Label-free quantitation Proteome Gingival inflammation Periodontitis Pct 
TranscriptomicsExpression data from gingival tissue
The experiment aims to identify transcriptional effects differences between periimplantitis, Parodontitis and healthy gingival tissue 8 controls, 7 periimplantitis patients, 7 Parodontitis patients
ORGANISM(S): Homo sapiens 
2012-10-29 | E-GEOD-33774 | biostudies-arrayexpress
TranscriptomicsExpression profiling in HGF (Hereditary Gingival Fibromatosis) patients
To identify dysregulated genes in HGF (Hereditary Gingival Fibromatosis) patients, expression profiling was performed using Affymetrix Human Genome U133 plus 2.0 arrays. Total RNA was extracted from gingival tissue specimens excised from two non-syndromic HGF patients, siblings in one family, and th...
ORGANISM(S): Homo sapiens 
2019-12-31 | E-MTAB-7801 | biostudies-arrayexpress
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