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TranscriptomicsFOXA1 actively represses the molecular phenotype of basal breast cancers.
Breast cancer is a heterogeneous disease comprised of at least five major subtypes. Luminal subtype tumors confer a more favourable patient prognosis, which is in part, attributed to the Estrogen Receptor-alpha (ER) positivity and anti-hormone responsiveness of these tumors. Expression of the forkhe...
ORGANISM(S): Homo sapiens 
2012-03-09 | E-GEOD-31003 | biostudies-arrayexpress
UnknownExpression of Wnt3 activates Wnt/β-catenin pathway and promotes EMT-like phenotype in trastuzumab-resistant HER2-overexpressing breast cancer cells.
Not available
S-EPMC3732195 | biostudies-literature
TranscriptomicsExpression of p16 and Retinoblastoma Determines Response to CDK 4/6 Inhibition in Ovarian Cancer: Ovarian cancer cell line expression data.
PD-0332991 is a selective inhibitor of the CDK4/6 kinases with the ability to block retinoblastoma (Rb) phosphorylation in the low nanomolar range. Here we investigate the role of CDK4/6 inhibition in human ovarian cancer. We examined the effects of PD-0332991 on proliferation, cell-cycle, apoptosi...
ORGANISM(S): Homo sapiens 
2011-01-22 | E-GEOD-26805 | biostudies-arrayexpress
TranscriptomicsA panel of hepatocellular carcinoma cell lines recapitulates the molecular subtypes of the human disease: A model for targeted drug development
RNA expression patterns of liver cell lines were compared to those of liver tumors to determine the suitability of cell lines as a model for drug development studies. The cell lines appear to recapitulate liver tumors. Gene expression of 20 individual liver cell lines relative to a liver cell line ...
ORGANISM(S): Homo sapiens 
2012-02-15 | E-GEOD-35818 | biostudies-arrayexpress
TranscriptomicsA panel of breast cell lines
RNA expression patterns of breast cell lines were compared with a breast cell line mixed reference. Gene expression profiles of 52 individual breast cell lines relative to a breast cell line reference mix containing equal amounts of 10 breast cell lines.
ORGANISM(S): Homo sapiens 
2013-02-22 | E-GEOD-44552 | biostudies-arrayexpress
TranscriptomicsExpression changes following siRNA knockdown of ADRM1 in ovarian cell line OAW42
Knock-down of ovarian cancer amplification target ADRM1 leads to down regulation of GIPC1 and up-regulation of RECK. Among 20q13-amplified genes in ovarian cancer, ADRM1 overexpression was the most highly correlated with amplification, and was significantly upregulated with respect to stage, recurr...
ORGANISM(S): Homo sapiens 
2011-01-14 | E-GEOD-26634 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes in pancreatic adenocarcinoma [tumors, normal and pancreatitis]
The goal of the study was to examine the transcriptional profile of pancreatic tumors to identify molecular subtypes in order to develop validated clinically useful gene expression signature with the potential to guide therapy decision. Tissue was obtained by snap freezing in liquid nitrogen as soo...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-77858 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes in pancreatic adenocarcinoma [pancreatic cancer cell lines]
The goal of the study was to examine the transcriptional profile of pancreatic cancer cell lines and assess if the molecular subtypes observed in tumor samples were represented in existing cell line models. Cell line models allow us to investigate if the molecular subtype observed in tumor have uni...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-77850 | biostudies-arrayexpress
UnknownBeating the empty pelvis syndrome: the PelvEx Collaborative core outcome set study protocol.
Not available
S-EPMC10860036 | biostudies-literature
UnknownThe empty pelvis syndrome: a core data set from the PelvEx collaborative.
Not available
S-EPMC10921833 | biostudies-literature
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