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ProteomicsHistone PTM profiling during the cell cycle
To investigate how histone post-translational modifications (PTMs) change during the cell cycle, we profiled histone H3 and histone H4 in breast cancer and normal breast cell lines arrested in G1/S or G2/M phases.
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD013288 | Pride
Histone post-translational modifications Cell cycle Lc/ms Cell proliferation 
ProteomicsAlternative digestion approaches improve histone modification mapping by mass spectrometry in clinical samples
Profiling histone post-translational modifications (PTMs) in clinical samples holds great potential for the identification of epigenetic biomarkers and the discovery of novel epigenetic targets. We have recently developed a battery of mass spectrometry (MS)-based approaches to analyze histone PTMs i...
ORGANISM(S): Homo sapiens (Human) 
2010-10-08 | PXD009946 | Pride
Histone post-translational modifications Proteomics Epigenetics 
ProteomicsProfiling of epigenetic features in clinical samples reveals novel widespread changes in cancer
Aberrations in histone post-translational modifications (PTMs), as well as in the histone modifying enzymes (HMEs) that catalyze their deposition and removal, have been reported in many tumors, and many epigenetic inhibitors are currently under investigation for cancer treatment. Therefore, profilin...
ORGANISM(S): Homo sapiens (Human) 
2019-09-09 | PXD013311 | Pride
Cancer Proteomics Histone post-translational modifications Mass spectrometry Epigenetics 
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