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TranscriptomicsTranscription profiling of human dendritic cells to identify a combinatorial code by which DCs discriminate pathogens and provide (suggest) a rationale to design adjuvants for TH1 responses.
Toll like receptors (TLRs) sense microbial products and initiate adaptive immune responses by activating dendritic cells (DCs). Since pathogens may contain several agonists we asked whether different TLRs may synergize in DC activation. We report that in human and mouse DC TLR3 or TLR4 potently syne...
ORGANISM(S): Homo sapiens 
2007-09-14 | E-GEOD-2706 | biostudies-arrayexpress
Transcriptomicsendometrial_seq_submission
Endometrial biopsies from tumor (T), adjacent normal (N) and hyperplastic (H) tissue specimens (when available) were obtained by histeroscopy from 10 patients and 3 healty donor. RNA isolated from these samples was used to perform smallRNA-Seq by NGS and gene expression profiling by microarrays in ...
ORGANISM(S): Homo sapiens 
2015-04-01 | E-MTAB-2795 | biostudies-arrayexpress
TranscriptomicsDemethyl fructiculin A (SCO-1) induces apoptosis by inducing reactive oxygen species in mitochondria
Demethyl fructiculin A is a diterpenoid quinone component of the exudates from Salvia corrugata (SCO-1) leafes. SCO-1 was recently reported to induce anoikis in mammalian cell lines via a molecular mechanism involving the presence of the membrane scavenging receptor CD36. However, experiments perfor...
ORGANISM(S): Homo sapiens 
2010-10-15 | E-GEOD-19846 | biostudies-arrayexpress
Transcriptomicsendometrial_array_submission
Endometrial biopsies from tumor (T), adjacent normal (N) and hyperplastic (H) tissue specimens were obtained by histeroscopy from 5 patients
ORGANISM(S): Homo sapiens 
2015-04-01 | E-MTAB-2796 | biostudies-arrayexpress
UnknownDepletion of ATP-Citrate Lyase (ATPCL) Affects Chromosome Integrity Without Altering Histone Acetylation in Drosophila Mitotic Cells.
Not available
S-EPMC6458238 | biostudies-literature
TranscriptomicsIdentification of novel genes associated with human glioblastoma (GBM) tumor-initiating cells (TICs)
Most patients affected by Glioblastoma multiforme (GBM) experience a recurrence of the disease because of the spreading of tumor-initiating cells (TICs) beyond surgical boundary. Unveiling and targeting molecular mechanisms causing this process is a logic goal to impair GBM killing ability. In an or...
ORGANISM(S): Homo sapiens 
2012-09-11 | E-GEOD-16805 | biostudies-arrayexpress
TranscriptomicsIdentification of long non-coding RNA expression patterns useful for molecular-based classification of type I endometrial cancers
Endometrial cancer represents the most frequent gynecologic malignant disease. Although several genetic alterations have been associated with increased risk, to date diagnosis and prognosis still rely on morphological features of the tumor, such as histological type, grading and invasiveness. As mol...
ORGANISM(S): Homo sapiens 
2019-04-30 | E-MTAB-7039 | biostudies-arrayexpress
UnknownHDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers.
Not available
S-EPMC8108360 | biostudies-literature
UnknownTP53 regulates miRNA association with AGO2 to remodel the miRNA-mRNA interaction network.
Not available
S-EPMC4772015 | biostudies-literature
TranscriptomicsThe gamma secretase inhibitor LLNle induces apoptosis of human GBM tumor initiating cells
Glioblastomas (GBM) are poorly differentiated astrocytic tumors arising in the Central Nervous System (CNS), which despite aggressive treatments are still characterized by a fatal outcome. Several studies have shown the existence of a subpopulation of cells within glioma tumors displaying cancer ste...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14581 | biostudies-arrayexpress
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