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TranscriptomicsTranscription profiling of human lung cancer cell lines
These arrays are used for various projects Experiment Overall Design: HG-U133A and HG-U133B data are combined and analyzed together with other U133A & B or with HG-U133plus2 samples. No replicates were performed. Controls are human bronchial epithelial cells (HBECs)
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4824 | biostudies-arrayexpress
TranscriptomicsExpression profiling of lung cancer cell lines (UTSW Lung Panel V2)
Epithelial/mesenchymal transition (EMT) is associated with loss of cell adhesion molecules, such as E-cadherin, and increased invasion, migration, and proliferation in epithelial cancers. In non-small cell lung cancer (NSCLC), EMT is associated with greater resistance to EGFR inhibitors. However, it...
ORGANISM(S): Homo sapiens 
2012-10-25 | E-GEOD-32989 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human umbilical vein endothelial cells (HUVECs) transduced with pMLV-MCS or pMLV-THAP1 retroviral expression vectors
Goal of the experiment : Retroviral-mediated gene transfer of the THAP-zinc finger protein THAP1 inhibits endothelial cell proliferation through coordinated repression of critical cell cycle regulators and pRB-E2F target genes. Experimental design: To gain insight into the effects of THAP1 on endo...
ORGANISM(S): Homo sapiens 
2006-09-11 | E-TABM-24 | biostudies-arrayexpress
TranscriptomicsPrimary Lung Cancer Specimens
This SuperSeries is composed of the following subset Series: GSE31546: UMCCC Primary Lung Cancer Specimens GSE31547: MSKCC-A Primary Lung Cancer Specimens GSE31548: MSKCC-B Primary Lung Cancer Specimens Refer to individual Series
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-31908 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 40 NSCLC cell lines
INTRODUCTION: CDKN2A (p16) inactivation is common in lung cancer and occurs via homozygous deletions, methylation of promoter region, or point mutations. Although p16 promoter methylation has been linked to KRAS mutation and smoking, the associations between p16 inactivation mechanisms and other com...
ORGANISM(S): Homo sapiens 
2015-06-22 | E-GEOD-63882 | biostudies-arrayexpress
TranscriptomicsHuman lung epithelial cells progressed to malignancy through specific oncogenic manipulations
We have developed cdk4/hTERT-immortalized normal human bronchial epithelial cells (HBECs) to study lung cancer pathogenesis. By studying the oncogenic effect of common lung cancer alterations (p53, KRAS, and c-MYC) we demonstrate the ability of this model to characterize the stepwise transformation...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-40828 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 275 lung cancer specimens
From ~1,700 non-small cell lung cancer specimens collected at the MD Anderson Cancer Center over the years 1997 to 2005, we selected 914 tumors with detailed clinical and pathological information. We extracted RNA and DNA from frozen tissues using histology quality control from 700 cases. RNA was ex...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-41271 | biostudies-arrayexpress
TranscriptomicsUMCCC Primary Lung Cancer Specimens
Develop an EGFR mutation gene expression signature to aid in predicting response and clinical outcome and to identify genes associated with the EGFR-dependent phenotype 17 primary lung adenocarcinomas were analyzed with Affymetrix U133-plus2
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-31546 | biostudies-arrayexpress
TranscriptomicsExpression profiling of 83 matched pairs of lung adenocarcinomas and non-malignant adjacent tissue
Background: Non-small cell lung cancers (NSCLCs) consist of adenocarcinoma (ADC), squamous cell carcinoma (SCC) and other types. Since most NSCLCs are now diagnosed from small biopsies or cytology materials, classification is not always accurate. This is a problem as many therapy regimens and clinic...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-75037 | biostudies-arrayexpress
TranscriptomicsMSKCC-A Primary Lung Cancer Specimens
Develop an EGFR mutation gene expression signature to aid in predicting response and clinical outcome and to identify genes associated with the EGFR-dependent phenotype 30 primary lung adenocarcinomas and 20 adjacent normal lung controls were analyzed with Affymetrix U133A
ORGANISM(S): Homo sapiens 
2011-09-05 | E-GEOD-31547 | biostudies-arrayexpress
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