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TranscriptomicsExpression data from WT and Aire KO thymic medullary epithelial cells (MECs)
The aim of this study is to analyze the transcriptional effects of Aire deficiency in the thymus, using the Affymetrix MoGene platform to analyze variation in exon usage MECs were isolated from 4-6 wk-old WT or Aire KO ((B6xNOD)F1 background) mice. Three WT and three Aire-KO mice taken individually ...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-33878 | biostudies-arrayexpress
TranscriptomicsSirt1 is essential for Aire-mediated induction of central immunological tolerance
Autoimmune regulator (Aire) is a unique transcriptional regulator that induces promiscuous expression of thousands of tissue-restricted antigens (TRAs) in medullary thymic epithelial cells (mTECs), a step critical for induction of immunological self-tolerance. Although several recent studies provide...
ORGANISM(S): Mus musculus 
2015-05-25 | E-GEOD-68190 | biostudies-arrayexpress
Unknown<i>PFMG2025</i>-integrating genomic medicine into the national healthcare system in France.
Not available
S-EPMC11910791 | biostudies-literature
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