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TranscriptomicsExpression data of human trophectoderm cells
The implantation process begins with attachment of the trophectoderm (TE) of the blastocyst to the maternal endometrial epithelium. Herein we have investigated the transcriptome of mural TE cells from 13 human blastocysts and compared these with those of human embryonic stem cell (hESC)-derived-TE (...
ORGANISM(S): Homo sapiens 
2011-09-08 | E-GEOD-30650 | biostudies-arrayexpress
TranscriptomicsTranscriptomic Signature of Trophoblast Differentiation in a Human Embryonic Stem Cell Model
Identification of genes involved in trophoblast differentiation is of great interest in understanding cellular and molecular mechanisms involved in placental development and is relevant clinically to fetal development, fertility, and maternal health. To understand, on a global scale, changes in the ...
ORGANISM(S): Homo sapiens 
2011-09-16 | E-GEOD-30915 | biostudies-arrayexpress
TranscriptomicsKrM-CM-
Endometriosis is characterized by progesterone resistance and is associated with infertility. KrM-CM-
ORGANISM(S): Homo sapiens 
2012-04-03 | E-GEOD-31683 | biostudies-arrayexpress
TranscriptomicsUnexpected Inflammatory Effects of Intravaginal Gels (Universal Placebo Gel and Nonoxynol-9) on the Upper Female Reproductive Tract: an Experimental Crossover Study
Intravaginal HIV microbicides could provide women with a self-controlled means for HIV prevention, but results from clinical trials have been largely disappointing. We postulated that unrecognized effects of intravaginal gels on the upper female reproductive tract (FRT) might contribute to the lower...
ORGANISM(S): Homo sapiens 
2015-08-10 | E-GEOD-58090 | biostudies-arrayexpress
TranscriptomicsPerivascular Human Endometrial Mesenchymal Stem Cells Express Pathways Relevant to Self-Renewal, Lineage Specification, and Functional Phenotype
A population of endometrial cells displaying key properties of mesenchymal stem cells (eMSC) has been identified in human endometrium. eMSC co-express CD146 and PDGFRB surface markers, have a perivascular location, and likely represent the reservoir of progenitors giving rise to the endometrial str...
ORGANISM(S): Homo sapiens 
2011-11-14 | E-GEOD-31152 | biostudies-arrayexpress
TranscriptomicsChanges in eutopic endometrial gene expression during the progression of experimental endometriosis in the baboon, Papio anubis
Endometriosis is associated with aberrant gene expression in the eutopic endometrium of women with disease. To determine if the development of endometriotic lesions directly impacts eutopic endometrial gene expression, we sequentially analyzed the eutopic endometrium across the time course of diseas...
ORGANISM(S): Papio anubis 
2015-08-27 | E-GEOD-72428 | biostudies-arrayexpress
TranscriptomicsSeminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts.
Exposure of eEC and eSF to SP in vitro increases expression of genes and secreted proteins associated with cellular migration, proliferation, viability and inhibition of cell death. This is a cross sectional study involving control samples versus treatment. SP (pooled from twenty donors) was first t...
ORGANISM(S): Homo sapiens 
2014-05-07 | E-GEOD-57356 | biostudies-arrayexpress
ProteomicsStructure dynamics of ApoA-I amyloidogenic variants in small HDL increase their ability to mediate cholesterol efflux
Specific mutations in Apolipoprotein A-I (ApoA-I) of high-density lipoprotein (HDL) are responsible for a late-onset systemic amyloidosis. Carriers do not exhibit increased cardiovascular disease risk despite reduced levels of ApoA-I/ HDL-cholesterol. To explain this paradox, we show that the HDL pa...
ORGANISM(S): Homo sapiens (Human) 
2020-11-20 | PXD021266 | Pride
Hdx-ms Amyloidogenic apoa-i variants 
ProteomicsGFP pulldown for the RiboVD project
GFP-tagged viral peptide sequences and their controls were used to pull down interactors from human (uninfected) or green monkey (viral infected) cell lysate. After sample preparation, digestion and bottom-up LC-MS/MS analysis, the enriched proteins were identified.
ORGANISM(S): Homo sapiens (Human) Cercopithecus aethiops (Green monkey) (Grivet) 
2023-03-09 | PXD033874 | Pride
Pulldown Motif Virus Interaction Coronavirus 
UnknownIdentifying therapeutic candidates for endometriosis through a transcriptomics-based drug repositioning approach.
Not available
S-EPMC10952035 | biostudies-literature
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