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GenomicsThe human TTAGGG Repeat Factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats
The study of the proteins that bind to telomeric DNA in mammals has provided a deep understanding of the mechanisms of chromosome-end protection. However, very little is known on the binding of these proteins to nontelomeric DNA sequences. The TTAGGG DNA repeat proteins 1 and 2 (TRF1 and TRF2) bind ...
ORGANISM(S): Homo sapiens 
2011-05-03 | E-GEOD-26005 | biostudies-arrayexpress
TranscriptomicsReduced expression of RhoE promotes ROCK-dependent invasion in transformed human fibroblasts
Cen3tel cells, obtained by telomerase immortalization of human fibroblasts, gradually underwent neoplastic transformation and became metastatic in immunocompromised mice. Neoplastic transformation was associated with a change in cell morphology (from fibroblastic to polygonal). Tumorigenic cells acq...
ORGANISM(S): Homo sapiens 
2011-04-20 | E-GEOD-15742 | biostudies-arrayexpress
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