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MetabolomicsA conserved metabolic signature associated with response to fast-acting antimalarial agents

Characterizing the mode of action of antimalarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to inform on the mechanism of action of antimalarial leads ...

2023-09-27 | MTBLS6580 | MetaboLights
MetabolomicsSmall Polar Hits against S. aureus: Screening, Initial Hit Optimization, and Metabolomic Studies
The global prevalence of antibacterial resistance requires new antibacterial drugs with novel chemical scaffolds and modes of action. It is also vital to design compounds with optimal physicochemical properties to permeate the bacterial cell envelope. We described an approach of combining and integr...
2021-11-04 | MTBLS788 | MetaboLights
UnknownTrends in socioeconomic inequalities in underweight and obesity in 5-year-old children, 2011-2018: a population-based, repeated cross-sectional study.
Not available
S-EPMC7986667 | biostudies-literature
MetabolomicsUntargeted metabolomics to understand the basis of phenotypic differences in amphotericin B-resistant Leishmania parasites

BACKGROUND: Protozoan Leishmania parasites are responsible for a range of clinical infections that represent a substantial challenge for global health. Amphotericin B (AmB) is increasingly used to treat Leishmania infection, so understanding the potential for resistance to this d...

2019-09-26 | MTBLS1167 | MetaboLights
UnknownEqual accuracy for Andrew and Abubakar-detecting and mitigating bias in name-ethnicity classification algorithms.
Not available
S-EPMC9910274 | biostudies-literature
MetabolomicsAmphotericin B resistance in Leishmania mexicana: Alterations to sterol metabolism, lipid transport and oxidative stress response

Amphotericin B is increasingly used in treatment of leishmaniasis. Here, fourteen independent lines of Leishmania mexicana and one L. infantum line were selected for resistance to either amphotericin B or the related polyene antimicrobial, nystatin. Sterol profiling revealed tha...

2022-09-22 | MTBLS2744 | MetaboLights
MetabolomicsMetabolomic profiling of macrophages determines the discrete metabolomic signature and metabolomic interactome triggered by polarising immune stimuli
Priming and activating immune stimuli have profound effects on macrophages, however, studies generally evaluate stimuli in isolation rather than in combination. In this study we have investigated the effects of pro-inflammatory and anti-inflammatory stimuli either alone or in combination on macropha...
2018-03-13 | MTBLS570 | MetaboLights
UnknownA cohort analysis of men with a family history of BRCA1/2 and Lynch mutations for prostate cancer.
Not available
S-EPMC4960816 | biostudies-literature
ProteomicsViral lncRNA upregulates multiple A+U-richViral lncRNA upregulates multiple A+U-rich transcripts to promote cell motility and viral dissemination transcripts to promote cell motility and viral dissemination
Long non-coding RNAs are frequently associated with broad modulation of gene expression and thus provide the cell with the ability to synchronize entire metabolic processes. We used transcriptomic and proteomic approaches to investigate whether the most abundant human cytomegalovirus-encoded lncRNA,...
ORGANISM(S): Human herpesvirus 5 strain Merlin Homo sapiens (Human) 
2021-07-27 | PXD022277 | Pride
Cell motility Gene regulation Lncrna A+u rich Transcriptomics Human cytomegalovirus Viral dissemination 
MetabolomicsVeterinary trypanocidal benzoxaboroles are peptidase-activated prodrugs (T. brucei assay)

Livestock diseases caused by Trypanosoma congolense, T. vivax and T. brucei, collectively known as nagana, are responsible for billions of dollars in lost food production annually. There is an urgent need for novel therapeutics. Encouragingly, promising antitrypanosomal benzoxaboroles are under v...

2020-09-23 | MTBLS1474 | MetaboLights
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